TNP631 - CLINICAL NEUROIMMUNOLOGY I
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| CLINICAL NEUROIMMUNOLOGY I | TNP631 | Any Semester/Year | 3 | 2 | 4 | 10 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Question and Answer Preparing and/or Presenting Reports Drill and Practice Case Study Problem Solving Brain Storming | |||||
| Instructor (s) | Prof. Dr. Meryem Aslı Tuncer | |||||
| Course objective | To examine the mechanisms of nervous system injury caused by immune attacks on various disease models. | |||||
| Learning outcomes |
| |||||
| Course Content | Neuroimmunology and genetics, pathophysiology of neuromuscular junction disorders, inflammatory and demyelinating disorders of the nervous system and immune pathogenesis. | |||||
| References | 1. Villoslada P. Genain CP. Role of nerve growth factor and other trophic factors in brain inflammation. Prog Brain Res. 2004;146: 403-14. 2. Bradl M. Hohlfeld R. Molecular pathogenesis of neuroinflammation. J. Neurol Neurosurg Psychiatry. 2003 Oct; 74 (10): 1364-70. 3. Kornek B. Lassmann H. Neuropathology of multiple sclerosis-new concepts. Brain Res Bull. 2003 Aug 15; 61 (3): 321-6. 4. Neumann H. Molecular mechanisms of axonal damage in inflammatory central nervous system diseases. Curr Opin Neurol. 2003 Jun; 16 (3): 267-73. 5. Wekerle H. Hohlfeld R. Molecular mimicry in multiple sclerosis. N. Engl J. Med. 2003 Jul 10; 349 (2):185-6 | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Principles of autoimmunity, basic mechanisms in neuro-immunology |
| Week 2 | Molecular mechanisms in neuro-immunology (cytokines, Integrins, adhesion molecules) |
| Week 3 | Important second messanger systems in neuro-immunology |
| Week 4 | The pathogenesis and pathology of acute demyelination in childhood |
| Week 5 | Chronic-recurrent demyelination in chiIdhood |
| Week 6 | Presentation of the project |
| Week 7 | Viral autoimmunity |
| Week 8 | The regenerating effect of inflamation |
| Week 9 | The immunology of pain |
| Week 10 | Immune response and immuno-therapy of brain tumors |
| Week 11 | Immuno-modulatory therapies |
| Week 12 | The immune response to hypoxia-ischemia in the child and Immature brain |
| Week 13 | Immunology of epilepsy |
| Week 14 | Ä°mmune profile of central nervous system - Neurogenic Inflamation |
| Week 15 | |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 14 | 10 |
| Laboratory | 0 | 0 |
| Application | 14 | 10 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 10 | 10 |
| Presentation | 10 | 10 |
| Project | 2 | 10 |
| Seminar | 0 | 0 |
| Midterms | 0 | 0 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 0 | 50 |
| Percentage of final exam contributing grade succes | 0 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 14 | 2 | 28 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 3 | 42 |
| Presentation / Seminar Preparation | 10 | 9 | 90 |
| Project | 2 | 15 | 30 |
| Homework assignment | 10 | 5 | 50 |
| Midterms (Study duration) | 0 | 0 | 0 |
| Final Exam (Study duration) | 1 | 20 | 20 |
| Total Workload | 65 | 57 | 302 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. He/She becomes familiar with the scientific advanced knowledge in the field of Clinical Neurological and Psychiatric Sciences and has the ability to use the information received. | X | ||||
| 2. He/She is able to follow recent national and/or international publications in the clinical neurological and psychiatric sciences, especially about the candidate's own field of study, use the information obtained from these references and acquires the latest literature knowledge about the scientific studies he/she is conducting. | X | ||||
| 3. He/She obtains enough scientific information, statistical knowledge and technical experience in the field of Clinical Neurological and Psychiatric Sciences so that he/she will be able to evaluate the recent researches that are being presented at both national and international congresses and propose his/her opinion. In addition he/she may evaluate the studies at a level that is sufficient to be a referee for scientific journals. | X | ||||
| 4. At the end of the program, the candidate becomes an example, especially with his scientific knowledge and skills in his / her field. He/She can conduct joint projects with researchers from other fields and transfer his/her own knowledge to new beginners. Candidate has the ability to reach information efficaciously, and compare the previously obtained data with his/her own data and make critical assessment. | X | ||||
| 5. Candidate becomes an independent investigator, especially in his / her area of interest, and transfers his/her experiences to beginners. He/She can set up his/her own laboratory and compose a working team, and has the capacity to design and implement new methods. | X | ||||
| 6. Candidate follows up-to-date technical information and is prone to apply new methods. He/she is open to all kinds of ideas, can discuss their advantages and disadvantages ,and he/she has the ability to criticize these ideas with all aspects. He/She is open-minded for multidisciplinary work and contributes to the work. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest