EAG610 - METHODS USED ON THE ANALYSIS of PHARMACEUTICAL AND
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| METHODS USED ON THE ANALYSIS of PHARMACEUTICAL AND | EAG610 | Any Semester/Year | 3 | 0 | 3 | 5 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Experiment Problem Solving | |||||
| Instructor (s) | Program Academic Staff | |||||
| Course objective | Gaining the theoretical and practical knowledge and background to the students about the titrimetric and spectroscopic methods using in pharmaceutical industry. | |||||
| Learning outcomes |
| |||||
| Course Content | The basic principles of titrimetric and spectroscopic methods and application of these methods on the pharmaceutical and biopharmaceutiical analyses. | |||||
| References | 1. D.C. Harris, Quantitative Chemical Analysis, Seventh Edition, W.H. Freeman and Company, USA, 2007. 2. D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch, Analitik Kimya Temel İlkeler, 1. Cilt, Çeviri Editörleri: Esma Kılıç, Hamza Yılmaz, 8. Baskı, Bilim Yayınları, 2007. 3. D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch, Fundamentals of Analytical Chemistry, Eighth Edition, Brooks Cole, 2004. 4. H. A. Flaschka, A. J. Barnard, P. E. Sturrock, Analitik Kimya, Çeviri Editörleri: Prof. Dr. Özer Bekaroğlu, Y. Doç. Dr. Ahmet Gül, Y. Doç. Dr. Nükhet Tan, İ.T.Ü. Elektrik Elektronik Fakültesi Ofset Atölyesi (1987). 5. J. D. Ingle, S. R. Crouch, Spectrochemical Analysıs, Prentice-Hall, USA (1988). 6. B. Welz, Atomic Absorption Spectrometry, Second, Complete Revised Edition, Meersburg (1985). | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | The basic principles of titration, definitions and indicators |
| Week 2 | Classification of titratiom methods |
| Week 3 | Neutralisation an precipitation titrations |
| Week 4 | Redox and complexometric titrations |
| Week 5 | Instrumental analysis titrations: Karl Fischer, potentiometric, amperometric titrations |
| Week 6 | Instrumental analysis titrations: onductometric and photometric titrations |
| Week 7 | Midterm exam |
| Week 8 | The basic principles of spectrophotometric methods |
| Week 9 | Ultaviolet(UV) -Visible Spectroscopy, Derivative Spectroscopy |
| Week 10 | Atomic Spectroscopy |
| Week 11 | Ä°nfrared (IR) Spectroscopy |
| Week 12 | Raman Spectroscopy |
| Week 13 | Fluoresence spectroscopy |
| Week 14 | Application of titrimetric methods on the analysis of pharmaceuticals and biopharmaceuticals |
| Week 15 | Application of spectroscopic methods on the analysis of pharmaceuticals and biopharmaceuticals |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 50 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 1 | 50 |
| Percentage of final exam contributing grade succes | 1 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 3 | 4 | 12 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 2 | 28 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 1 | 28 | 28 |
| Final Exam (Study duration) | 1 | 40 | 40 |
| Total Workload | 33 | 77 | 150 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Has knowledge in the area of preformulation and formulation designs about industrial production, quality control, quality assurance system and stability | |||||
| 2. Acquires information about nanotechnology, new drug delivery systems and controlled release systems | |||||
| 3. Learns to keep track of up to date literature and patents using the knowledge and informatics technologies | X | ||||
| 4. Interprets the guidelines of health authorities such as FDA, EMA and international guidelines such as GMP, ANDA, BA/BE, QA/QC, acquires application knowledge and skills | X | ||||
| 5. Has knowledge to understand and interpret chemical, instrumental and pharmacological data | |||||
| 6. Has basic concepts about medicinal chemistry such as design of new drug molecules, drug-receptor interactions | |||||
| 7. Has the knowledge on the rules of scientific ethics which should be complied | X | ||||
| 8. Effectively uses the conventional and new synthetic methods. | |||||
| 9. Has knowledge of advanced toxicity tests accepted by regulatory authorities | |||||
| 10. Has knowledge about pharmacological experimental methods and their applications used in drug research and evaluates analysis results | |||||
| 11. Has knowledge about preclinical and clinical drug research | |||||
| 12. Has knowledge about the pharmacokinetic and pharmacodynamic properties of drugs | |||||
| 13. Has knowledge about the pharmacokinetics and pharmacodynamics of drugs | X | ||||
| 14. Has knowledge of and the ability to use the devices and instruments used in the application of instrumental analysis methods | X | ||||
| 15. Has the ability to apply theoretical and practical knowledge in the analysis of substances in medicinal products and biological materials | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest