BÄ°K754 - CLINICAL LABORATORY TECHNIQUES III

Course Name Code Semester Theory
(hours/week)
Application
(hours/week)
Credit ECTS
CLINICAL LABORATORY TECHNIQUES III BÄ°K754 Any Semester/Year 3 2 4 10
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Question and Answer
Drill and Practice
 
Instructor (s)Assoc.Prof.Dr. Oytun Portakal, Prof.Dr. Z.Günnur Dikmen 
Course objectiveThe course objective is to learn the clinical laboratory management, operation, safety, quality control, laboratory information system, acceptance and rejection criteria of samples, diagnostic tests and their interpretation, evidence-based medicine. 
Learning outcomes
  1. 1) Students have advanced theoretical and practical knowledge in the field of clinical biochemistry and develop them.
  2. 2) Students have advanced level of knowledge in clinical biochemistry laboratory equipment and tools that are specific to an advanced level of knowledge, are skilled in the use of them.
  3. 3) They have advanced knowledge in clinical biochemistry tests and can use the principles of evidence-based medicine to interprete them.
  4. 4) They follow new tests and evidence-based practices in their field, conduct research and design, implement new tests independently for the benefit of society.
  5. 5) They lead to solve scientific problems related to their and interdisciplinary fields, suggest alternative solutions using strategic decision-making processes, critically analyze new informations, evaluate and interpret.
  6. 6) They have the ability to handle a clinical or research laboratory alone and have managerial and training features to make strategic decisions.
  7. 7) They contribute to the solutions of the problems related to social, scientific, cultural and ethical issues in the health field and support the development of these values.
Course ContentClinical Biochemistry Laboratory management;Renal pathophysiology and biochemistry, tests of renal function;Routine urine analysis;Basic hematology and coagulation tests;Clinical enzymology and methods of measurement;Cardiovascular pathophysiology and laboratory;Clinical biochemistry of endocrine systems;Clinical biochemistry of nutrition and gastrointestinal system;Pediatric and geriatric clinical biochemistry;Metabolism and laboratory of iron, porphyrin and bilirubin, analyses of extravascular body fluids, cerebrospinal fluid, synovial fluid,serous body fluids;Bones, joints and connective tissue pathophysiology and laboratory;Neoplasia, tumor markers, therapeutic drugs and their measurement methods;Biochemistry and laboratory of inherited metabolic diseases;Interpretation of analyzes, reference values, evidence-based laboratory medicine;Clinical laboratory quality control and management, quality standards of the Ministry of Health, tender and cost analysis in clinical laboratories. 
ReferencesLawrence A. Kaplan Amadeo Pesco, Steven Kazmierczak. Clinical Chemistry: Theory, analysis, correlation 4th edition and 5th edition.
Alan H.B WU. Tietz. Laboratuvar testler. (Çeviri) 4. Baskı. (2011)
Carl A. Burtis, Edward R. Ashwood. Tietz. Klinik Kimyada temel ilkeler. (Çeviri) 5. Baskı (2005)
Shauna C. Anderson, Susan Cockayne. Clinical Chemistry. Concepts and applications (2007)
Norbert W. Tietz. Clinical guide to laboratory tests. 3rd edition. (1995)
Larry E. Schoeff. Principles of laboratory ınstruments.(1993)
Segel I. Biochemical Calculations. How to solve mathematical problems in general biochemistry. (1976)
 

Course outline weekly

WeeksTopics
Week 1Clinical Biochemistry Laboratory management, safety, laboratory information system, automation, sample collection, transport, acceptance and rejection criterias and storage
Week 2Renal pathophysiology and biochemistry,tests of renal function,laboratory of kidney diseases and transplantation.Routine urine analysis, liquid-electrolyte and acid-base balance and measurement methods, blood gas measurement systems, point of care.
Week 3Basic hematology and coagulation tests, molecular hematology
Week 4Clinical enzymology and methods of measurement, pancreas pathophysiology, diabetes mellitus, liver pathophysiology and their laboratory
Week 5Cardiovascular pathophysiology and laboratory
Week 6Clinical biochemistry of endocrine systems, immunodiagnostic analyzers and interferences.
Week 7Clinical biochemistry of nutrition and gastrointestinal system, methods of measurement of vitamins and trace elements.
Week 8Pediatric and geriatric clinical biochemistry
Week 9Metabolism and laboratory of iron, porphyrin and bilirubin, analyses of extravascular body fluids, cerebrospinal fluid, synovial fluid, and serous body fluids.
Week 10Bones, joints and connective tissue pathophysiology and laboratory
Week 11Neoplasia, tumor markers, therapeutic drugs and their measurement methods.
Week 12Biochemistry and laboratory of inherited metabolic diseases
Week 13Interpretation of analyzes, reference values, evidence-based laboratory medicine.
Week 14Clinical laboratory quality control and quality management, quality standards of the Ministry of Health, tender and cost analysis in clinical laboratories.
Week 15Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory1420
Application1415
Field activities00
Specific practical training00
Assignments115
Presentation00
Project00
Seminar00
Midterms00
Final exam150
Total100
Percentage of semester activities contributing grade succes3050
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 14 2 28
Application14114
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)1414196
Presentation / Seminar Preparation000
Project000
Homework assignment133
Midterms (Study duration)199
Final Exam (Study duration) 188
Total Workload5940300

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. The student has advanced theoretical and practical knowledge on biochemistry and enhances this knowledge.    X
2. Knows professional ethics (intellectual property, academic integrity, ethics in human relations: avoids discrimination, values merit, respects privacy etc), research and publication ethics and applies this information.    X
3. Reviews and analyzes the recent literature on a specific subject, formulates a unique hypothesis from this analysis and writes a project on this subject.     X
4. Has advanced knowledge on the uses of instruments and methods specific to the field of biochemistry as well as other technological equipment including computers and uses them in the course of projects.     X
5. Independently can head a project-based scientific work from start to finish, finalize the work, analyze the data through relevant statistical methods and contributes to progress in the field.    X 
6. Follows evidence based applications, does research and contributes to produce knowledge which can be put to good use in society.    X
7. Writes the report of the research participated in or made by self and contributes to universal knowledge by publishing it in a peer-reviewed journal and presenting it at scientific meetings.     X
8. Can formulate alternative solutions to scientific problems in the field and critically analyze and evaluate new information.     X
9. Takes part in national and international multi-disciplinary studies both as leader or participant and through effective communication can relay distinctive ideas in scientific discussions and provides feed-back.     X
10. Can independently manage a research laboratory and has managing and teaching skills for making strategic decisions.     X
11. Is open to renovation and in continuous self development.     X
12. Even without any previous experience, can structure and apply a method on if needed.    X
13. Is in command of native language, can communicate at an advanced level using written, oral and visual techniques and debates.     X
14. Has proficiency in English both to follow the advances in the field and to contribute to it using written, oral and visual techniques.     X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest