ADB751 - CHEMISTRY and BIOSYNTHESIS of NATURAL
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| CHEMISTRY and BIOSYNTHESIS of NATURAL | ADB751 | Any Semester/Year | 3 | 0 | 3 | 8 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Question and Answer Preparing and/or Presenting Reports | |||||
| Instructor (s) | Prof. Dr. Adil Denizli, Assoc. Prof. Dr. Handan Yavuz | |||||
| Course objective | Steroids are the structural components of cell membranes and important hormones. They have a characteristic four ring structure. Terpenes are sequential and double bond containing hydrocarbon chains. Steroids are synthesized from simple three carbon terpene units (isoprene). These substances are the precursors of many important hormones and compounds as well as used in the synthesis of illicit and doping compounds, anabolic-and rogenic steroids. For these reasons, knowing the chemistry of the synthesis and the metabolites of these compounds is an important issue. In this lecture, biosynthesis of the natural compounds from simple precursors will be represented. | |||||
| Learning outcomes |
| |||||
| Course Content | Origin, properties and synthesis of different class of natural products (terpenes, steroids, alkaloids ...etc), Definition and importance of natural products, Techniques used in the isolation of natural products, Steroid compounds, Flavonoid compounds, Terpenoid compounds: monoterpenes, sesquiterpenes, triterpenes | |||||
| References | 1. Medicinal Chemistry of Bioactive Natural Products, Xiao-TianLiang, Wei-Shou Fabg, John Wiley and Sons, 2006. 2. Bioactive Compounds from Natural Sources, CorradoTringali (Eds) Taylor & Francis, New York, 2001 3. Biochemistry, LubertStryer, W.H. Freeman and Company, 2000 | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Classification of Natural Products |
| Week 2 | Studying With Natural Products |
| Week 3 | Isoprenoidcompounds |
| Week 4 | Terpenehydrocarbons |
| Week 5 | SteroidsI |
| Week 6 | Mıd term Exam |
| Week 7 | Steroids II |
| Week 8 | Synthesis of Steroids |
| Week 9 | Biosynthesis I |
| Week 10 | Biosynthesis II |
| Week 11 | Nitrogen Containing Natural Products I |
| Week 12 | Nitrogen Containing Natural Products II |
| Week 13 | Semester performance evaluation |
| Week 14 | Semester performance evaluation |
| Week 15 | Preportion for final exam |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 1 | 20 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 30 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 0 | 50 |
| Percentage of final exam contributing grade succes | 0 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 9 | 126 |
| Presentation / Seminar Preparation | 1 | 30 | 30 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 1 | 20 | 20 |
| Final Exam (Study duration) | 1 | 20 | 20 |
| Total Workload | 31 | 82 | 238 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Based on the graduate level proficiency improves and deepens the actual and advanced knowledge with original thought and/or research in the level of specialty. | X | ||||
| 2. Comprehends interdisciplinary interaction related with his/her field; performs analysis and synthesis of the new and complex ideas and reaches the original results by using expert knowledge in assessment. | X | ||||
| 3. Evaluates and uses knowledge with systematic approach in his/her field; makes critical analysis, synthesis, and assessment of knowledge and transfer it. | X | ||||
| 4. Develops a new idea, method, design and/or application for innovation in his/her field or performs a known idea, method, design and/or application to a different field. Researches an original subject; comprehends, designs, adapts and implements them | X | ||||
| 5. Possesses the high level skills in using research methods in his/her field | X | ||||
| 6. Publishes at least one article related with his/her field in national or international academic journals. | X | ||||
| 7. Works in situation, which requires to solving original and interdisciplinary problems | X | ||||
| 8. Develops new ideas and methods related to his/her field using upper level intellectual processes such as innovative and critical thinking, solving problems and enacting. | X | ||||
| 9. Makes a scientific research at national or international academic groups | X | ||||
| 10. Contributes the solution of the social, scientific, cultural and ethical problems in his/her field and supports the improvement of these values | X | ||||
| 11. Presents the scientific and technologic progresses in his/her field, contributes the processes of being an information society where he/she lives and continuation of this. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest