KHB701 - BASIC CONCEPTS IN STEM CELL SCIENCES

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
BASIC CONCEPTS IN STEM CELL SCIENCES KHB701 1st Semester 3 0 3 8
PrequisitesShould code the course `KHB 703` in the same semester.
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Question and Answer
 
Instructor (s)Duygu UÇKAN ÇETÄ°NKAYA (Coordinator), Teaching Assistants: AyÅŸen GÃœNEL ÖZCAN; Fatima AERTS KAYA; Betül ÇELEBÄ° SALTIK; Fatma Visal OKUR; Lale KARAKOÇ-SÖKMENSÃœER 
Course objectiveThe aim of this course is familiarize the students with what stem cells are, pluripotency mechanisms, stem cell types, stem cell varieties in the postnatal organism besides embryonic and fetal stages, how to obtain pluripotent stem cells from somatic cells and tell about cancer stem cells; In addition, it is planned to transfer basic information on topics like characteristics of the niche wherein the stem cells are found and stem cell dynamics, cell-cell and cell-matrix interactions, signalling pathways. 
Learning outcomes
  1. Definition of stem cells, their characteristics, self-renewal, differentiation and pluripotentcy concepts
  2. Stem cell types, isolation and characteristics of stem cells from tissues obtained during the prenatal and postnatal stage,
  3. Knowledge concerning on how to procure induced pluripotent stem cells from somatic cells and the characteristics of these cells,
  4. The concept of cancer stem cells and learn the basic characteristics of these cells,
  5. The stem cell niche concept,
  6. Knowlege about stem cell traffick, niche ingress egress, cell-cell and cell-matrix interactions,
  7. Basic knowledge on signalling pathways,
  8. The wound healing processes with the evolutionary perspective.
Course ContentDefinition, types and characteristics of stem cells
Embryonic stem cells and fetal stem cells
Adult stem cells (predominantly, Hematopoietic and Mesenchymal Stem Cells)
Induced pluripotent stem cells,
Cancer Stem Cells
Signalling pathways
Stem cell niche, extracellular matrix, adhesion molecules, cytokines and chemokines
Role of stem cells in wound healing 
ReferencesEssentials of Stem Cell Biology Second Edition?, Editors: Lanza R, Gearhart J, Hogan B et al, 2009 Elsevier Inc., ISBN 978-0-12-374729-7
www.stembook.org
`Biology of Stem Cells and the Molecular Basis of Stem Cell State? Dov Zipori, Humana Press, 2009, ISBN 978-1-60761-129-5
Literature to be specified to the students before the classes 

Course outline weekly

WeeksTopics
Week 1Definition of Stem cells, Terminology and Classes (Duygu UÇKAN-ÇETİNKAYA)
Week 2Embryonic Stem Cells (Lale KARAKOÇ-SÖKMENSÜER/Ayşen GÜNEL-ÖZCAN)
Week 3Fetal Stem Cells (Betül ÇELEBİ-SALTIK)
Week 4Adult Stem Cells -I: Hematopoetic Stem Cell and Hematopoesis (Duygu UÇKAN-ÇETİNKAYA)
Week 5Adult Stem Cells II: Mesenchymal Stem Cell (Fatima AERTS-KAYA)
Week 6Cancer Stem Cells (Fatma Visal OKUR)
Week 7Midterm exam
Week 8Microenvironment- Niche Concept / Stem Cell Trafficking (Duygu UÇKAN-ÇETİNKAYA - Fatima AERTS KAYA)
Week 9Cytokines, Chemokines and Signalling Pathways (Fatima AERTS- KAYA)
Week 10Extracellular Matrix and Tissue Engineering (Betül ÇELEBİ-SALTIK)
Week 11Induced pluripotent stem cells (Fatima Visal OKUR)
Week 12Stem Cells and Regeneration (Ayşen GÜNEL-ÖZCAN)
Week 13Applications of Regenerative Medicine/Ethical Approaches (Duygu UÇKAN-ÇETİNKAYA)
Week 14Article
Week 15Discussion
Week 16Final Exam

Assesment methods

Course activitiesNumberPercentage
Attendance1410
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments430
Presentation00
Project00
Seminar00
Midterms120
Final exam140
Total100
Percentage of semester activities contributing grade succes1960
Percentage of final exam contributing grade succes140
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14684
Presentation / Seminar Preparation000
Project000
Homework assignment41664
Midterms (Study duration)12020
Final Exam (Study duration) 13030
Total Workload3475240

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. They will know, understand, analyze and assess basic concepts/mechanisms of stem cells    X
2. Find hypothetical solution suggestions to questions/problems related to stem cell concepts and sciences   X 
3. Find solutions to stem cell-related problems through hypothetical analyses and develop approaches for applications  X  
4. Understand, know stem cell procedures, plan, write and execute science-based projects     
5. Follow and apply developments related to the stem cells    X
6. Use state-of-the-art information technology produced in their line of work effectively     
7. Own knowledge and skills required to discuss stem cell sciences and related topics at an international level    X
8. Discuss and defend opinions on theoretic and practical topics in a scientific environment     
9. Report and publish the results of their stem cell research     
10. Know ethical principles of stem cell research. Know its importance for individuals and society and respect ethical principles     
11. Inform people about topics related to stem cell sciences; know standards of stem cell laboratory applications, can apply biosafety rules     
12. Gain knowledge on stem cells and cellular treatments for clinical applications, use their knowledge in clinic-directed research     
13. Gain information and knowledge to work in the frame of the regulatory office and/or take responsibility for a stem cell/cellular treatment production-processing facility     

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest