KAB605 - CELL MEMBRANE and SIGNAL TRANSDUCTION MECHANISMS

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
CELL MEMBRANE and SIGNAL TRANSDUCTION MECHANISMS KAB605 1st Semester 3 0 3 8
PrequisitesNone
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Question and Answer
Preparing and/or Presenting Reports
 
Instructor (s)Prof. Dr. GüneÅŸ EsendaÄŸlı, Doç. Dr. Hande Canpınar, Doç.Dr. Gürcan Günaydın, Doç.Dr. NeÅŸe Ãœnver, Doç.Dr. Begüm Kocatürk 
Course objectiveTo learn the structure and properties of the cellular membranes as well as the mechanisms of signal recognition, transduction and their relevance with oncogenesis. Students are in charge of reading the suggested references for each lesson and of preparing a seminar presentation. 
Learning outcomes
  1. To know the principal components and features of the cell
  2. To understand the principal features and functions of the cellular molecules
  3. To understand the synthesis and localization of the signalling molecules
  4. To learn the fundamental features of the cellular signalling
  5. To understand the molecules and mechanisms of signal transduction
  6. To understand the physiologic responses of normal and neoplastic signalling
  7. To learn to ask original questions about molecular interactions
Course ContentThe biochemical features of the cell membrane, nucleus membrane, the transport mechanisms of the cell membrane, membrane energy transfer and transport ATPase, principle features and mediator molecules of the signal transduction, G-protein coupled signal transduction pathways, enzyme mediated receptors (receptor tyrosine kinase) signalling, signal transduction molecules and mechanisms of apoptosis, growth factors and their signalling pathways, signal transduction pathways of the oncogenes, multi-drug resistance proteins and their mechanisms (P-glycoprotein, MRP, LRP), cancer and epigenetics, hypoxia and cancer. 
References1. Principles of Biochemistry, A.L. Lehninger, D.L. Nelson, M.M. Cox
2. Molecular Biology of the Cell, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
3. Nature Reviews, Cancer
4. Trends in Biochemistry
5. Cellular Signaling Journal 

Course outline weekly

WeeksTopics
Week 1General Properties of Cancer
Week 2Cell Membrane and Biochemical Properties
Week 3Membrane Transition Mechanisms
Week 4General Characteristics of Signal Transduction
Week 5Protein Mediated Receptors
Week 6Enzyme Mediated Receptors
Week 7Growth factors and their signalling pathways
Week 8Cell cycle and its signal transduction
Week 9Energy Metabolisms in Cancer Cells
Week 10Protein Metabolism in Cancer Cell
Week 11Inflammatory Signaling Pathways in Cancer
Week 12Signal Transduction Mechanisms in Metastatic Cells
Week 13Targeting Signal Transduction Pathways in Cancer
Week 14Hypoxia and Signal Transduction
Week 15General Exam Preparation
Week 16Final Examination

Assesment methods

Course activitiesNumberPercentage
Attendance1410
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation120
Project00
Seminar00
Midterms00
Final exam170
Total100
Percentage of semester activities contributing grade succes1530
Percentage of final exam contributing grade succes170
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)1014140
Presentation / Seminar Preparation12828
Project000
Homework assignment000
Midterms (Study duration)000
Final Exam (Study duration) 13030
Total Workload2675240

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. At the end of this program, each student is expected to comprehend the innate and adaptive immune functions as well as the basic immunologic principles. X    
2. At the end of this program, each student is expected to comprehend the diseases that develop with the contribution of the immune system or the diseases that result from the impairment of immune mechanisms.X    
3. At the end of this program, each student is expected to learn the classification, nomenclature and mechanisms of immunologic disorders as well as the basic properties of immunopathology. X    
4. At the end of this program, each student is expected to comprehend the basic and differential properties as well as the development mechanisms of immunological disorders seen in various systems. X    
5. At the end of this program, each student is expected to learn how to follow the novel improvements and advances in immunology. X    
6. At the end of this program, each student is expected to learn to be able to ask original questions related to immunology as well as to choose and apply the appropriate methods and techniques in order to find an answer to the relevant questions.X    
7. At the end of this program, each student is expected to successfully and correctly perform basic immunological and molecular techniques. X   
8. At the end of this program, each student is expected to gain the necessary skills and competence in the preparation of scientific reports, abstracts and presentations as well as to write scientific articles in peer-reviewed journals.    X
9. At the end of this program, each student is expected to sensitively and completely accord with the ethical issues related to the field as well as to be able to work and take responsibilities as a member of the team.     
10. At the end of this program, each student is expected to complete a research study during his/her training in the program, to learn the adequate literature knowledge about his/her study topic, to write his/her dissertation for master?s degree, to compare and to discuss the relevant information in the literature with his/her own findings.    X
11. At the end of this program, each student is expected to demonstrate a critical approach to the discussed methods in journal clubs, seminars and data presentations as well as to successfully express his/her thoughts and concerns, and to be able to support his/her ideas with the information from relevant literature.    X
12. At the end of this program, each student is expected to know and apply the laboratory safety and accreditation rules and regulations related to immunology.     
13. At the end of this program, each student is expected to know, apply and follow the methods for statistical analyses and evidence-based applications at a level sufficient to read and evaluate a scientific article. X   
14. At the end of this program, each student is expected to combine the information about his/her field of study with the information from different disciplines, to interpret this information to generate new information, to analyze and synthesize novel ideas.    X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest