HÄ°S788 - DEVELOPMENT & HISTOLOGY of THE SKIN & ITS APPENDIC

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
DEVELOPMENT & HISTOLOGY of THE SKIN & ITS APPENDIC HÄ°S788 Any Semester/Year 2 0 2 5
Prequisites-
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Team/Group Work
Preparing and/or Presenting Reports
Problem Solving
 
Instructor (s)Prof. Petek Korkusuz, MD, PhD., Assist. Prof. Elif Karakoç, MD 
Course objectiveThe aim is to learn the embryologic development and histology of the integumentary system (skin and its appendages) at the molecular level including their congenital anomalies. The skin associated lymphoid system and the regenerative capacity of the skin will be also discussed with its progenitor cell capacity. 
Learning outcomes
  1. 1. To learn the embryologic development of epidermis and the dermis
  2. 2. To learn the embryologic development of skin appendages
  3. 3. To learn the histology and histophysiology of epidermal layers with their cells
  4. 4. To identify the dermal cellular and extracellular components with a histologic point of view
  5. 5. To describe the histological structure and histophysiology of skin appendages at the molecular level
  6. 6. To learn the progenitor cell content and the regenerative capacity of the skin
  7. 7. To understand skin as a lymphoid organ
Course ContentThe skin and it appendages will be considered as a big organ. Thus the embryologic development of both the epidermis and dermiÅŸ will be discussed at the molecular level with thir congeniatl abnormalities. The histophysiology of epidermel layers and cells (keratinocytes, melanocytes, Merkel cells, Langerhans cells) will be detailed. The dermal cells and extracellular matrix components will be explained with skin appendages; sweat and sebaceous glands, hair and nail. The progenitor cell content of the skin and its healing capacity will be introduced.  
References1. Human Embryology and Developmental Bıology. BM Carlson.
2. Developing Human: Clinically Oriented Embryology. KL Moore, TVN Persaud, MG Torchia.
3. Before We Are Born. KL Moore, TVN Persaud, MG, Torchia.
4. Langman's Medical Embryology. TW Sadler.
5. Histology: A Text and Atlas: MH Ross, W Pawlina. 

Course outline weekly

WeeksTopics
Week 1The embryologic development of epidermis and dermis
Week 2The embryologic development of sebaceous and sweat glands
Week 3The embryologic development of hair follicles, hairs and nails
Week 4The molecular mechanisms mediating skin and its appendages development
Week 5Congenital abnormalities of the skin
Week 6Histology and histophysiology of the keratinocytes
Week 7Histology and histophysiology of the melanocytes, Merkel cells and Langerhans cells
Week 8Dermal layers
Week 9The molecular structure of the dermal cells and extracellular matrix components)
Week 10Histology and histophysiology of sbecaeous glands hairs and nails
Week 11Midterm exam
Week 12Skin progenitor cells
Week 13Healing capacity of the skin and the contribution of stem cells for regeneration
Week 14Skin as an immune organ (skin associated lymphoid tissue), Immune response in skin
Week 15Preparation to final exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance285
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments210
Presentation15
Project00
Seminar15
Midterms125
Final exam150
Total100
Percentage of semester activities contributing grade succes3350
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation2816
Project000
Homework assignment2816
Midterms (Study duration)11010
Final Exam (Study duration) 11010
Total Workload3443150

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. Know the light and electron microscobic structure of the cells, tissues and organs; understanding the molecular and genetic components, establish the relationship between the structure function.    X
2. Understanding of the molecular mechanisms regulating human embryonic development , should be able to define the developmental disorders.   X 
3. Know the basic techniques such as histochemistry, immunohistochemistry, electron microscopy, cell culture.     
4. Must know and apply microscopic imaging techniques together and other quantitative methods such as stereology.  X  
5. Must have the basic knowledge and competence necessary to perform laboratuary works such as IVF, stem cell technologies in cooperation with the clinics.     
6. Must have knowledge, skills and attitudes that will contribute to education.  X  
7. Should know how to obtain information to improve self and understand the importance of continuous learning.   X 
8. Be able to put forward original hypotheses independently; plan and write original projects.     
9. Have information and views on ethical issues on science and publication ethics and clinically related IVF and stem cell studies.     
10. Be capable to participate in national and international scientific environments , make presentations and discussions.     
11. Understand the evaluation criteria of the national and international journals and evaluate an article or project independently.      

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest