HÄ°S777 - BONE & JOINT HEALING & ITS INTERACTION WITH BIOMAT

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
BONE & JOINT HEALING & ITS INTERACTION WITH BIOMAT HÄ°S777 Any Semester/Year 2 0 2 5
Prequisites-
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Team/Group Work
Preparing and/or Presenting Reports
Problem Solving
 
Instructor (s)Prof. Petek Korkusuz, MD, PhD., Prof. Pergin Atilla, MD, PhD.  
Course objectiveTo gain knowledge and the skill at the level to relate with clinics in bone forming and resorption process, molecular steps of fracture healing, skeletal tissue engineering applications, development and immunohistologic components of the joints, ligaments, tendons, fasciae, menisci and synovial membranes, and their repair mechanisms 
Learning outcomes
  1. To define musculoskeletal system tissues cell & matrix elements
  2. To learn hard tissue laboratory techniques, experimental animal models
  3. To learn bone with its inorganic and organic components including cell-cell, cell-matrix interactions at the molecular level. To learn ossification, bone formation, resorption and remodeling processes analyzing cellular mediator mechanisms
  4. To discuss bone repair, fracture healing phases with at the molecular level.
  5. To define the development and histology of joints and synovial membranes: Interzones and associated structures. To understand cell matrix organization for synovium.
  6. To explain the repair processes of joints; evaluate the role of the synoviocyte layer
  7. To learn the cell and extracellular matrix components of tendon, ligament, fascia, meniscus at the molecular level. Regenerative potential and repair mechanisms of tendon, ligament, fascia, meniscus; To discuss with current tissue engineering approaches.
  8. To have up-to-date knowledge of biomaterials and skeletal tissue engineering applications at the molecular level at the cell-tissue level
Course ContentMusculoskeletal system consists of soft and hard structural elements such as bone, muscle, cartilage, tendon, ligament, fascia and meniscus. Bone is considered as the main organ of skeletal system with its calcified extracellular matrix and dynamic cellular components. Ossification, bone formation, resorption and remodeling processes are tightly mediated by molecular interaction of cells, cytokines and other matrix components. The muscles, cartilages, tendons, ligaments support the bony skleton by their cells and extracellular matrix elements. These tissues will be discussed at the molecular level with special insight to their regenerative capacities. The development and histology of joints and synovial membranes will be evaluated including cell-cell and cell-matrix interaction mediating molecules. Joint repair will be discussed with special attention to synovial lining layer immune response. 
References1. Human Embryology and Developmental Bıology. BM Carlson.
2. Developing Human: Clinically Oriented Embryology. KL Moore, TVN Persaud, MG Torchia.
3. Before We Are Born. KL Moore, TVN Persaud, MG, Torchia.
4. Langman's Medical Embryology. TW Sadler.
5. Ortophaedic Basic Science: Foundations of Clinical Practice. Einhorn TA, OKeefe RJ, Buckwalter J;
6. Histology: A Text and Atlas. MH Ross, W Pawlina.
7. Tissue Engineering in Musculoskeletal Practice. Sandell LJ, Grodzinsky AJ.
8. Biomaterials in Orthopedics,. Yassemzemski MJ, Trantolo DJ, KU Lewandrowski KU.
9. Human Embryology and Developmental Bıology. BM Carlson.
10. Developing Human: Clinically Oriented Embryology. KL Moore, TVN Persaud, MG Torchia.
11. Before We Are Born. KL Moore, TVN Persaud, MG, Torchia.
12. Langman's Medical Embryology. TW Sadler. 

Course outline weekly

WeeksTopics
Week 1Introduction to musculoskeletal system: Development and histology of bone, cartilage and associated tissues
Week 2Cartilage with its cell-cell, cell-matrix interactions at the molecular level
Week 3Bone with its inorganic and organic components including cell-cell, cell-matrix interactions at the molecular level.
Week 4Hard tissue laboratory techniques, experimental animal models
Week 5Endochondral and intramembraneous ossification. Regulation of ossification, bone formation, resorption and remodeling processes analyzing cellular mediator mechanisms
Week 6Bone and cartilage repair, fracture healing phases at the molecular level
Week 7Midterm exam
Week 8Development and histology of joints and synovial membranes: Interzones and associated structures.
Week 9Specific histologic organization for synovium: synoviocytes and subsynovial tissue
Week 10Joint repair phases with special reference to synovial membranes
Week 11Immunologic response for synovium: with special attention to cell surface antigens
Week 12Development and histology of tendons ligaments, faciae and associated structures, The regenerative capacty of tendons ligaments, faciae and associated structures; tissue engineering perspectives
Week 13Skeletal tissue engineering based on musculoskeletal histophysiology principles: Biomaterial applications
Week 14Biomaterial-tissue interaction: Biocompatibility
Week 15Preparation to final exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance285
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation110
Project00
Seminar110
Midterms125
Final exam150
Total100
Percentage of semester activities contributing grade succes3150
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation2612
Project000
Homework assignment000
Midterms (Study duration)12020
Final Exam (Study duration) 12020
Total Workload3253150

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. Know the light and electron microscobic structure of the cells, tissues and organs; understanding the molecular and genetic components, establish the relationship between the structure function.    X
2. Understanding of the molecular mechanisms regulating human embryonic development , should be able to define the developmental disorders.   X 
3. Know the basic techniques such as histochemistry, immunohistochemistry, electron microscopy, cell culture.    X
4. Must know and apply microscopic imaging techniques together and other quantitative methods such as stereology.   X 
5. Must have the basic knowledge and competence necessary to perform laboratuary works such as IVF, stem cell technologies in cooperation with the clinics.     
6. Must have knowledge, skills and attitudes that will contribute to education.   X 
7. Should know how to obtain information to improve self and understand the importance of continuous learning.  X  
8. Be able to put forward original hypotheses independently; plan and write original projects.  X  
9. Have information and views on ethical issues on science and publication ethics and clinically related IVF and stem cell studies.  X  
10. Be capable to participate in national and international scientific environments , make presentations and discussions.  X  
11. Understand the evaluation criteria of the national and international journals and evaluate an article or project independently.  X   

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest