HÄ°S762 - ORAL EMBRYOLOGY and HISTOLOGY

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
ORAL EMBRYOLOGY and HISTOLOGY HÄ°S762 Any Semester/Year 2 0 2 5
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Team/Group Work
Preparing and/or Presenting Reports
Problem Solving
 
Instructor (s)Prof. Sevda MüftüoÄŸlu, MD, PhD., Prof. Petek Korkusuz, MD, PhD 
Course objectiveEvaluation of the the development and histology of oral structures including the controlling molecular mechanisms, the antigenic profiles; malformations and, their clinical manifestations  
Learning outcomes
  1. 1. Acquisition of the development of Palate, nasal cavity and septum, tongue, salivary glands
  2. 2. Acquisition of defining tooth, root development, eruption and shedding
  3. 3. Acquisition to discussing molecular factors and induction mechanisms involved in development of the teeth and associated structures Components of periodontium: Cementum, alveolar bone, periodontal ligament and their congenital abnormalities with their clinical significance
  4. 4. Acquisition of discussing histological features of oral mucosa including regional differences, renewal, repair Histological components of enamel and dentin in accordance with their apposition and maturation process; dentin ?pulp complex
  5. 5. Acquisition of defining gingival and, dentogingival junctional tissues histologic components, cellular renewal potentials
Course ContentThe odontogenesis starts between the sixth and seventh weeks of gestation with the appearance of dental lamina. Tooth development occurs in accordance with the development of other orofacial structures (palate, nasal cavity and septum, tongue, salivary glands). The process is influenced by a series of induction mechanisms mediated via multiple genetic factors. Oral mucosa presents regional differences regarding its histologic features and renewal capacity. Enamel, dentin and pulp function in an integrative manner with their specific histologic components. Periodontium is the supporting tissue of the teeth with its specific components (cementum, alveolar bone, periodontal ligament). Molecular mechanisms involved in the development and structural integration of oral structures, causes of congenital malformations will be discussed in association with clinic. 
References1) Nanci A. Ten Cate?s Oral Histology, Development, Structure, ad Function
2) Bath-Balogh M, Fehrenbach MJ: Illustrated Dental Embryology, Histology and Anatomy
3) Gartner LP, Hiatt JL: Color Textbook of Histology/concise Histology.
4) Moore KL, Persaud TVN: The Developing Human. Clinically Oriented Embryology.
5) Larsen WJ: Human Embryology.
6) Sadler T.W., Langman J: Langman's Medical Embryology. 

Course outline weekly

WeeksTopics
Week 1Fertilization, implantation, formation of bilaminar and trilaminar embryonic discs
Week 2Further development of mesoderm, prechordal plate, neurulation
Week 3Development and congenital abnormalities of the palate, nasal cavity and septum, tongue, salivary glands
Week 4Tooth development
Week 5Root development, Congenital malformations related to tooth and root development
Week 6Eruption and shedding; molecular mechanisms
Week 7Genetic factors and induction mechanisms involved in development of the teeth and associated structures congenital abnormalities with their clinical significance
Week 8Midterm exam
Week 9Histologic features of oral mucosa including regional differences, renewal, repair and aging
Week 10Histologic components of enamel in accordance with its apposition and maturation process
Week 11Histologic components of dentin in accordance with its apposition and maturation process
Week 12Histologic components of pulp: dentin-pulpa complex
Week 13Gingival and, dentogingival junctional tissues histologic components, cellular renewal potentials , Components of periodontium: cementum, alveolar bone, periodontal ligament
Week 14Discussion and paper presentation
Week 15Preparation to final exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance285
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation115
Project00
Seminar115
Midterms115
Final exam150
Total100
Percentage of semester activities contributing grade succes3150
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation11212
Project000
Homework assignment11010
Midterms (Study duration)11010
Final Exam (Study duration) 12020
Total Workload3259150

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. Know the light and electron microscobic structure of the cells, tissues and organs; understanding the molecular and genetic components, establish the relationship between the structure function.   X 
2. Understanding of the molecular mechanisms regulating human embryonic development , should be able to define the developmental disorders.  X  
3. Know the basic techniques such as histochemistry, immunohistochemistry, electron microscopy, cell culture.     
4. Must know and apply microscopic imaging techniques together and other quantitative methods such as stereology.     
5. Must have the basic knowledge and competence necessary to perform laboratuary works such as IVF, stem cell technologies in cooperation with the clinics.     
6. Must have knowledge, skills and attitudes that will contribute to education.     
7. Should know how to obtain information to improve self and understand the importance of continuous learning. X   
8. Be able to put forward original hypotheses independently; plan and write original projects. X   
9. Have information and views on ethical issues on science and publication ethics and clinically related IVF and stem cell studies.X    
10. Be capable to participate in national and international scientific environments , make presentations and discussions.X    
11. Understand the evaluation criteria of the national and international journals and evaluate an article or project independently.      

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest