HÄ°S775 - UROGENITAL and ENDOCRINE SYSTEMS

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
UROGENITAL and ENDOCRINE SYSTEMS HÄ°S775 3rd Semester 2 0 2 5
Prequisites-
Course languageTurkish
Course typeMust 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Question and Answer
Drill and Practice
Brain Storming
 
Instructor (s)Prof. Pergin Atilla, MD, PhD, Assist. Prof. Elif Karakoç, MD 
Course objectiveTo identify the development and molecular mechanisms, malformations and histological features of urogenital system, endocrine system and mammary glands. 
Learning outcomes
  1. To be able to explain the development of female and male genital system organs and to establish clinical correlations with malformations.
  2. To explain the molecular mechanisms that are effective during the development of the female and male genital systems.
  3. To be able to explain the histological structure of the female and male genital system organs at light and electron microscope level and to establish clinical correlations with structural changes.
  4. To be able to explain the development of urinary system organs and to establish clinical correlations with malformations.
  5. To explain the molecular mechanisms that are effective during the development of the urinary system.
  6. To be able to explain the histological structure of the urinary system organs at light and electron microscope level and to establish clinical correlations with structural changes.
  7. Learning the histological structures of organs of endocrine system, synthesis and secretion of hormones. Understanding hypo- and hyperfunction on morphological and functional perspective.
  8. To be able to explain the development of endocrine system organs and to establish clinical correlations with malformations.
Course ContentDevelopment of kidney, urinary bladder and urinary excretory system will be discussed. Anomalies, molecules expressed during development of urinary system and correlations with clinical problems will be discussed. Histological structure of kidneys, urinary bladder and urinary excretory ducts will be identified under light microscope.
Oogenesis, spermatogenesis and molecules that regulate these are discussed. Development of male & female genital systems are discussed beginning from fertilization. Histology of male & female genital systems and mammary glands are explained by the aid of a microscope. Development and histological structures of hypophysis, epiphysis, thyroid gland, parathyroid gland, adrenal gland, diffuse endocrine system and interactions with each other will be discussed. Structures will be identified under light microscope 
References1. Moore KL, Persaud TVN: The Developing Human. Clinically Oriented Embryology.
2. Larsen WJ: Human Embryology.
3. Sadler T.W., Langman J: Langman's Medical Embryology.
4. Ross MH, Kaye GI, Pawlina W: Histology. A Text and Atlas.
5. Gartner L P, Hiatt J L : Histology.
6. Young B, Heat J W : Functional Histology. 

Course outline weekly

WeeksTopics
Week 1Stages of development of human kidney: Development of pronephros, mesonephros, metanephros, Development of ureteric bud, urinary excretory system, urinary bladder and urethra. Molecular regulation of development, anomalies and clinical correlations
Week 2Nephron: Histology of glomerulus, proximal tubule, distal tubule and loop of Henle, juxtaglomerular apparatus, renal intersitium
Week 3Histology of urinary bladder and urethra. Functional and structural correlations of urinary system compartments.
Week 4Germ cells, oogenesis, spermatogenesis; determination of sex Development of gonads and molecular mechanisms effecting the development
Week 5Development of genital excretory ducts: indifferent stage, differentiation in male and female and molecular mechanisms that effects the development, descend of testes to scrotum, External genital organs: Indifferent stage in male and female,
Week 6Midterm exam, presentation and discussion
Week 7Histology of ovarium, uterus, uterine tubes and external genital organs.
Week 8Histology of testes, male genital excretory ducts and male external genital organs
Week 9Ductal epithelial invagination in mammary gland development, role of mesenchyme and experimental studies. Histology of mammary glands and changes in lactation.
Week 10Congenital malformations and molecular mechanisms
Week 11Literature and discussion
Week 12Development and histology of hypophysis, epiphysis (Light and electron microscopic and molecular level)
Week 13Histology and development of thyroid, parathyroid and adrenal glands (Light and electron microscopic and molecular level)
Week 14Histology and development of endocrine pancreas and DNES (Light and electron microscopic and molecular level)
Week 15Preparation to final exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance285
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments210
Presentation15
Project00
Seminar00
Midterms130
Final exam150
Total100
Percentage of semester activities contributing grade succes4550
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation11212
Project000
Homework assignment2510
Midterms (Study duration)11010
Final Exam (Study duration) 12020
Total Workload3354150

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. Know the light and electron microscobic structure of the cells, tissues and organs; understanding the molecular and genetic components, establish the relationship between the structure function.    X
2. Understanding of the molecular mechanisms regulating human embryonic development , should be able to define the developmental disorders.    X
3. Know the basic techniques such as histochemistry, immunohistochemistry, electron microscopy, cell culture.     
4. Must know and apply microscopic imaging techniques together and other quantitative methods such as stereology.     
5. Must have the basic knowledge and competence necessary to perform laboratuary works such as IVF, stem cell technologies in cooperation with the clinics.     
6. Must have knowledge, skills and attitudes that will contribute to education.   X 
7. Should know how to obtain information to improve self and understand the importance of continuous learning.     
8. Be able to put forward original hypotheses independently; plan and write original projects.  X  
9. Have information and views on ethical issues on science and publication ethics and clinically related IVF and stem cell studies.     
10. Be capable to participate in national and international scientific environments , make presentations and discussions. X   
11. Understand the evaluation criteria of the national and international journals and evaluate an article or project independently.  X   

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest