EFG707 - SECONDARY METABOLITES-PHENOLIC COMPOUNDS

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
SECONDARY METABOLITES-PHENOLIC COMPOUNDS EFG707 2nd Semester 4 0 4 8
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
 
Instructor (s)Prof. Dr. AyÅŸe UZ, Prof. Dr. Didem SOHRETOGLU, Assoc. Prof. Dr. Dilek ERCIL 
Course objectiveTo give basic concepts on phenylpropanoids, simple phenol glycosides, coumarins lignans xanthons flavonoids tannins antranoids and naphthalens and their usage in the field of Pharmacognosy and Pharmacy 
Learning outcomes
  1. Comprehending the importance of phenylpropanoid, simple phenol glycoside, phenylethanoid glycoside, lignan, coumarin, xanthone, flavonoid, tannin, anthranoid, naphtoquinone compounds obtained from plants in terms of Pharmacognosy and Pharmacy
  2. Learning the general properties and chemical structures of simple phenols and their glycosides, simple phenol glycoside?containing drugs and their biological effects and usage.
  3. Learning the general properties and chemical structures of phenylpropanoids, phenylpropanoid ?containing drugs and their biological effects and usage.
  4. Learning the general properties and chemical structures of phenylethanoid glycosides, phenylethanoid glycoside ?containing drugs and their biological effects and usage.
  5. Learning the general properties and chemical structures of lignans, lignan ?containing drugs and their biological effects and usage.
  6. Learning of the general properties and the chemical structure of coumarins, coumarin ?containing drugs and their biological effects and usage.
  7. Learning of the general properties and the chemical structure of flavonoids, flavonoid ?containing drugs and their biological effects and usage. Learning of the general properties and the chemical structure of xanthones, xanthone ?containing drugs and their biological effects and usage. Learning of the general properties and the chemical structure of anthranoids, anthranoid ?containing drugs and their biological effects and usage.
  8. Learning of the general properties and the chemical structure of naphtoquinones, naphtoquinone?containing drugs and their biological effects and usage. Learning of the general properties and the chemical structure of tannins, tannin?containing drugs and their biological effects and usage.
Course ContentBiosynthesis, classifications, physical and chemical properties of phenolic compounds, their origins and extraction methods, isolation and structure elucidation by spectroscopic methods, biological activity studies of phenolic compounds. 
References1.Trease and Evans: Pharmacognosy Wiley & Sons 1996.
2.Natural products of Woody Plants II, 1989.
3.Harborne, J.B., Mabry, T.J., The Flavonoids: Advances in Research, Chapman and Hall, New York, 1982
4.Scientific Reviews 

Course outline weekly

WeeksTopics
Week 1Introduction, charecteristics, identification, biosynthesis and classification of phenolic compouns
Week 2Definition of simple phenols and their glycosides, their classification, identification, isolation and prufication, structure elucidation by spectroscopic methods, simple phenol-containing drugs, their biological activities and usage
Week 3Definition of simple phenols: derivatives of phenolic acids, orcinol and floroglucinol, their classification, identification, isolation and purification, structure elucidation by spectroscopic methods, phenolic acids, orcinol and floroglucinol-containing drugs, their biological activities and usage
Week 4eDefinition of phenylpropanoids and phenylethanoid glycosides, their classification, identification, isolation and purification, structure elucidation by spectroscopic methods, phenylpropanoid and phenylethanoid glycoside-containing drugs, their biological activities and usage
Week 5Definition of lignans, their classification, identification, isolation and prufication, structure elucidation by spectroscopic methods, lignan-containing drugs, their biological activities and usage
Week 6Definition of coumarins, their classification, identification, isolation and prufication, structure elucidation by spectroscopic methods, their biological activities and usage
Week 7Definition of flavonoids, their classification, identification, isolation and purification, structure elucidation by spectroscopic methods
Week 8Isolation and purification of flavonoids, flavonoid-containing drugs, their biological activities and usage
Week 9Definition of xanthones, their classification, identification, isolation and prufication, structure elucidation by spectroscopic methods, xanthone-containing drugs, their biological activities and usage
Week 10Definition of anthranoids, their classification, identification, isolation and purification, structure elucidation by spectroscopic methods, anthranoid-containing drugs, their biological activities and usage
Week 11Definition of naphtoquinones, their classification, identification, isolation and prufication, structure elucidation by spectroscopic methods, naphtoquinone-containing drugs, their biological activities and usage
Week 12Definition of tannins, their classification, identification, isolation and purification, structure elucidation by spectroscopic methods
Week 13Isolation and purification properties of tannins, tannin-containing drugs, their biological activities and usage
Week 14Presentation
Week 15Preparation for final exam
Week 16FINAL EXAM

Assesment methods

Course activitiesNumberPercentage
Attendance560
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation00
Project00
Seminar00
Midterms00
Final exam1100
Total100
Percentage of semester activities contributing grade succes00
Percentage of final exam contributing grade succes1100
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 4 56
Laboratory 0 0 0
Application000
Specific practical training000
Field activities14228
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation11111
Project2510
Homework assignment10330
Midterms (Study duration)000
Final Exam (Study duration) 13535
Total Workload5665240

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. Able to identify, analyze, and assess biological effects of natural-sourced drugs and materials.    X
2. Able to access current scientific Pharmacognosy information proficiently.    X
3. Able to master the biosynthetic pathways, chemical structures, classification, chemical and biological properties, diagnosis, and quantification of primary and secondary metabolism products in natural resources.    X
4. Able to perform and interpret various analyses on natural compounds.    X
5. Able to extract, purify, and characterize new or known compounds.   X 
6. Able to assess biological effects of natural extracts and compounds.   X 
7. Able to access natural resources responsibly, with environmental awarenessX    
8. Able to advise health institutions and patients on public health matters.   X 
9. Able to conduct ethical pharmacognostical studies, adhering to laws.   X 
10. Able to utilize and evaluate information from reference sources effectively.   X 
11. Able to inform the public about natural products through media. X   
12. Able to develop healthcare quality improvement policies addressing health issues.X    
13. Able to utilize natural product knowledge to enhance societal health.   X 
14. Able to integrate pharmacognosy with other disciplines to propose solutions.X    
15. Able to provide scientific consultancy on natural products to relevant industries.  X  

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest