EFG706 - PRIMARY METABOLITES

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
PRIMARY METABOLITES EFG706 1st Semester 2 0 2 7
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
 
Instructor (s)Prof. Dr. AyÅŸe UZ, Assist. Prof .Dr. V. Murat KUTLUAY, Assist. Prof .Dr. Zeynep DOGAN 
Course objectiveTo emphasize the importance of primary metabolites, structures, general propoties, biogenesis of primary metabolites, drugs containing primary metabolites, biological activities of them, highlight of primary metabolites in the field of pharmacognosy 
Learning outcomes
  1. Learning importance of primary metabolites from the point of view of pharmacognosy and pharmacy.
  2. Learning of the general properties and the chemical structure of carbohydrates; high amount of carbohydrates containing drugs and their usage.
  3. Learning of plants and drugs used for industrial source of carbohydrates
  4. Learning of the general properties and the chemical structures of polysaccharides (fructans, galactans, uronic acid derivatives, musilages, aminosugars) and related drugs and their activities.
  5. Learning of the general properties and the chemical structures of fats obtained from natural sources; oil -containing drugs and their activities.
  6. Learning of the general properties, classification and the chemical structures of waxs, phospolipids; drugs containig them and their activities/usage.
  7. Learning of the general properties, classification, and the chemical structures of other lipids (aliphatic alcohols, esters, alkenes, alkynes, acetogenins); drugs containing them and their activities.
  8. Learning of the general properties, classification, and the chemical structures of amino acids, peptids, proteins, compounds has proteinic structues, hormones Learning of lectins and enzymes, enzyme inhibitors, and enzyme drugs
Course ContentChemistry of sugars, fats and proteins; place, importance and medicinal properties of primary metabolites in pharmacognosy and properties, importance and activities of important primary metabolite-containing medicinal plants 
References1. Dewick PM, Medicinal Natural Products, John Wiley&Sons LTD, 2. Edition, West Sussex, 2002.
2. Trease and Evans Pharmacognosy, Saunders Elsevier, 16. Edition, Philadelphia, 2009.
3. Notes of lecture 

Course outline weekly

WeeksTopics
Week 1Introduction, monosaccharides, oligosaccharides (disaccharides, disaccharide derivatives, oligosaccharides) : Definitions, Biogenesis, General properties
Week 2Polysaccharides (fructans, galactans, uronic acid derivatives, musilages, aminosugars)
Week 3Plants and drugs used for industrial source of carbohydrates and carbohydrate derivatives
Week 4Polysaccharides (musilages,musilages containing drugs, aminosugars)
Week 5Polysaccharides (musilages,musilages containing drugs, aminosugars)
Week 6Fruit acids, faty acids and esters (structures, general properties, quality control of them)
Week 7Oils obtained from natural sources (saturated, unsaturated oils)
Week 8Waxs, phospolipids
Week 9Other lipids (aliphatic alcohols, esthers, alkenes, alkynes, acetogenins)
Week 10Other compounds in the lipid group (aliphatic alcohols, esters, alkenes, alkynes, acetogenins)
Week 11Amino acids, peptids, proteins, ((structures, classifications, general properties)
Week 12Compounds has proteinic structues, hormones
Week 13Lectins and enzymes
Week 14Enzyme inhibitors, and enzyme drugs
Week 15Preparation for presentation
Week 16PRESENTATION

Assesment methods

Course activitiesNumberPercentage
Attendance300
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments150
Presentation150
Project00
Seminar00
Midterms00
Final exam00
Total100
Percentage of semester activities contributing grade succes050
Percentage of final exam contributing grade succes050
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14570
Presentation / Seminar Preparation13030
Project000
Homework assignment14040
Midterms (Study duration)000
Final Exam (Study duration) 14242
Total Workload31119210

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
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1. Able to identify, analyze, and assess biological effects of natural-sourced drugs and materials.    X
2. Able to access current scientific Pharmacognosy information proficiently.   X 
3. Able to master the biosynthetic pathways, chemical structures, classification, chemical and biological properties, diagnosis, and quantification of primary and secondary metabolism products in natural resources.    X
4. Able to perform and interpret various analyses on natural compounds.   X 
5. Able to extract, purify, and characterize new or known compounds.    X
6. Able to assess biological effects of natural extracts and compounds.   X 
7. Able to access natural resources responsibly, with environmental awarenessX    
8. Able to advise health institutions and patients on public health matters.  X  
9. Able to conduct ethical pharmacognostical studies, adhering to laws.X    
10. Able to utilize and evaluate information from reference sources effectively.  X  
11. Able to inform the public about natural products through media.   X 
12. Able to develop healthcare quality improvement policies addressing health issues.  X  
13. Able to utilize natural product knowledge to enhance societal health.   X 
14. Able to integrate pharmacognosy with other disciplines to propose solutions.   X 
15. Able to provide scientific consultancy on natural products to relevant industries.  X  

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest