BÄ°S605 - BIOSTATISTICS
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| BIOSTATISTICS | BÄ°S605 | Any Semester/Year | 3 | 0 | 3 | 7 |
| Prequisites | None | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion | |||||
| Instructor (s) | Prof. Erdem Karabulut, PhD - Prof. Pınar Özdemir, PhD - Assoc. Prof. Osman DAĞ, PhD | |||||
| Course objective | To teach basic statistical concepts and methods to students by examples and applications in health sciences, to provide understanding and evaluating the statistical analysis used in the literature of their own study fields. | |||||
| Learning outcomes |
| |||||
| Course Content | 1. Basic statistical concepts 2. Descriptive statistics 3. Theoretical distributions, normal distribution 4. Sampling distributions 5. Basic research designs 6. Basic sampling methods 7. Hypothesis tests 8. Measures of association 9. Linear regression analysis 10. Measures of risk, evaluation of diagnostic tests | |||||
| References | 1. Sümbüloglu K ve Sümbüloğlu V. Biyoistatistik. Seçkin Yayıncılık, Ankara, 2010. 2. Özdamar K. Pasw ile Biyoistatistik. Kaan Kitabevi, Eskişehir, 2013. 3. Alpar R. Spor, Sağlık ve Eğitim Bilimlerinden Örneklerle UYGULAMALI İSTATİSTİK ve GEÇERLİK-GÜVENİRLİK. Detay Yayıncılık, Ankara, 2018. 4. Daniel, Wayne W. Biostatistics 9th Edition, New York: John Wiley&Sons, 2013. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Basic statistical concepts such as: statistics and biostatistics, population, sample, statistic, parameter, data, variable, types of data, and etc. |
| Week 2 | Descriptive statistics: grouping the data, measures of central tendency, measures of location, histogram, bar graph, stem & leaf graph, box-plot, etc. |
| Week 3 | Descriptive statistics: measures of dispersion, error bar graph, etc. |
| Week 4 | Examining the association among the variables by tables and graphics: Cross tables, tables regarding descriptive statistics (mean, s. deviation, etc.), multivariate applications of basic graphics, scatter plots, etc. |
| Week 5 | Standardization (z and T scores). Theoretical distributions: Normal distribution, and normality transformations. Tests and graphs for normality. Sampling distributions and confidence intervals |
| Week 6 | 1st Midterm Examination |
| Week 7 | Research methods. Introduction to hypothesis tests: Aims and stages of hypothesis tests, possible types of errors, p and alpha values, power, effect size, decision process |
| Week 8 | Hypothesis tests: Parametric and nonparametric one sample tests. Parametric and nonmparametric independent two sample tests. |
| Week 9 | Hypothesis tests: Parametric and nonparametric k independent sample tests. |
| Week 10 | Hypothesis tests: : Parametric and nonparametric dependent two-sample tests). Parametric and nonparametric k dependent sample tests . |
| Week 11 | 2nd Midterm Examination |
| Week 12 | Measures of association: Pearson correlatin coefficient, Spearman correlation coefficient, Phi, Cramer V, Eta, etc. |
| Week 13 | Simple and multiple linear regression analysis. |
| Week 14 | Simple and multiple linear regression analysis and examining an article. |
| Week 15 | Preparation to final exam |
| Week 16 | Final Exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 12 | 30 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 2 | 20 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 0 | 50 |
| Percentage of final exam contributing grade succes | 0 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 6 | 84 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 12 | 4 | 48 |
| Midterms (Study duration) | 2 | 10 | 20 |
| Final Exam (Study duration) | 1 | 16 | 16 |
| Total Workload | 43 | 39 | 210 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Gaining up-to-date knowledge and experience regarding fetal and neonatal effects of high-risk pregnancies (maternal auto-immune, iso-immune and hypertensive diseases; teratogenic substance-drug or substance-alcohol use, non-immune hydrops fetalis, intrauterine-perinatal infections); problems about traumatic delivery and also diagnosis, treatment and management of these babies before, during and after delivery. | X | ||||
| 1. Gaining up-to-date knowledge and experience regarding fetal and neonatal effects of high-risk pregnancies (maternal auto-immune, iso-immune and hypertensive diseases; teratogenic substance-drug or substance-alcohol use, non-immune hydrops fetalis, intrauterine-perinatal infections); problems about traumatic delivery and also diagnosis, treatment and management of these babies before, during and after delivery. | X | ||||
| 1. Gaining up-to-date knowledge and experience regarding fetal and neonatal effects of high-risk pregnancies (maternal auto-immune, iso-immune and hypertensive diseases; teratogenic substance-drug or substance-alcohol use, non-immune hydrops fetalis, intrauterine-perinatal infections); problems about traumatic delivery and also diagnosis, treatment and management of these babies before, during and after delivery. | X | ||||
| 2. Gaining up-to-date knowledge and experience regarding development, maturation, surfactant metabolism of lungs, respiratory physiology in newborns, respiratory evaluation - follow-up, diagnostic approach to respiratory distress, ethiopathogenesis and advanced treatments of severe respiratory diseases of the newborn (respiratory distress syndrome, bronchopulmonary dysplasia, important congenital anomalies of the respiratory system), mechanical ventilation support in newborns | X | ||||
| 2. Gaining up-to-date knowledge and experience regarding development, maturation, surfactant metabolism of lungs, respiratory physiology in newborns, respiratory evaluation - follow-up, diagnostic approach to respiratory distress, ethiopathogenesis and advanced treatments of severe respiratory diseases of the newborn (respiratory distress syndrome, bronchopulmonary dysplasia, important congenital anomalies of the respiratory system), mechanical ventilation support in newborns | X | ||||
| 2. Gaining up-to-date knowledge and experience regarding development, maturation, surfactant metabolism of lungs, respiratory physiology in newborns, respiratory evaluation - follow-up, diagnostic approach to respiratory distress, ethiopathogenesis and advanced treatments of severe respiratory diseases of the newborn (respiratory distress syndrome, bronchopulmonary dysplasia, important congenital anomalies of the respiratory system), mechanical ventilation support in newborns | X | ||||
| 3. Gaining up-to-date knowledge and experience regarding hemodynamic evaluation and follow-up of newborns, cardiotonic drugs, diagnosis, ethiopathogenesis, management and advanced treatments of severe circulatory system diseases (congenital heart diseases, patent ductus arteriosus, arrhythmias, pulmonary hypertension), preoperative and postoperative care in congenital cardiac disaeses, ECMO treatment. | X | ||||
| 3. Gaining up-to-date knowledge and experience regarding hemodynamic evaluation and follow-up of newborns, cardiotonic drugs, diagnosis, ethiopathogenesis, management and advanced treatments of severe circulatory system diseases (congenital heart diseases, patent ductus arteriosus, arrhythmias, pulmonary hypertension), preoperative and postoperative care in congenital cardiac disaeses, ECMO treatment. | X | ||||
| 3. Gaining up-to-date knowledge and experience regarding hemodynamic evaluation and follow-up of newborns, cardiotonic drugs, diagnosis, ethiopathogenesis, management and advanced treatments of severe circulatory system diseases (congenital heart diseases, patent ductus arteriosus, arrhythmias, pulmonary hypertension), preoperative and postoperative care in congenital cardiac disaeses, ECMO treatment. | X | ||||
| 4. Gaining up-to-date knowledge and experience regarding prevention of central nervous system damage in newborns, central nervous system monitoring, ethiopathogenesis and advanced treatments of severe diseases of the central nervous system (perinatal hypoxic ischemic injury, hypoxic ischemic encephalopathy, bilirubin encephalopathy, kern icterus, intraventricular-intracranial hemorrhage, white matter injury, periventricular leukomalacia, congenital malformations of the central nervous system, neonatal convulsions, apnea), hypotonia, neuromuscular diseases, retinopathy of prematurity, diagnosis, treatment and management of pain in newborns, identification of newborns with neurological-developmental high-risk and their follow-up. | X | ||||
| 4. Gaining up-to-date knowledge and experience regarding prevention of central nervous system damage in newborns, central nervous system monitoring, ethiopathogenesis and advanced treatments of severe diseases of the central nervous system (perinatal hypoxic ischemic injury, hypoxic ischemic encephalopathy, bilirubin encephalopathy, kern icterus, intraventricular-intracranial hemorrhage, white matter injury, periventricular leukomalacia, congenital malformations of the central nervous system, neonatal convulsions, apnea), hypotonia, neuromuscular diseases, retinopathy of prematurity, diagnosis, treatment and management of pain in newborns, identification of newborns with neurological-developmental high-risk and their follow-up. | X | ||||
| 4. Gaining up-to-date knowledge and experience regarding prevention of central nervous system damage in newborns, central nervous system monitoring, ethiopathogenesis and advanced treatments of severe diseases of the central nervous system (perinatal hypoxic ischemic injury, hypoxic ischemic encephalopathy, bilirubin encephalopathy, kern icterus, intraventricular-intracranial hemorrhage, white matter injury, periventricular leukomalacia, congenital malformations of the central nervous system, neonatal convulsions, apnea), hypotonia, neuromuscular diseases, retinopathy of prematurity, diagnosis, treatment and management of pain in newborns, identification of newborns with neurological-developmental high-risk and their follow-up. | X | ||||
| 5. Gaining up-to-date knowledge and experience regarding development of immune system in newborns, immunization of premature newborns, neonatal infections, sepsis, necrotizing enterocolitis, probiotic use in newborns. | X | ||||
| 5. Gaining up-to-date knowledge and experience regarding development of immune system in newborns, immunization of premature newborns, neonatal infections, sepsis, necrotizing enterocolitis, probiotic use in newborns. | X | ||||
| 5. Gaining up-to-date knowledge and experience regarding development of immune system in newborns, immunization of premature newborns, neonatal infections, sepsis, necrotizing enterocolitis, probiotic use in newborns. | X | ||||
| 6. Gaining up-to-date knowledge and experience regarding fluid, electrolyte, acid-base balance disorders in newborns, acute kidney injury, disorders of coagulation system (bleeding and thrombosis), hypoglycemia, hereditary metabolic diseases, disorders of calcium-phosphorus metabolism, diagnosis, treatment and management of osteopenia of prematurity | X | ||||
| 6. Gaining up-to-date knowledge and experience regarding fluid, electrolyte, acid-base balance disorders in newborns, acute kidney injury, disorders of coagulation system (bleeding and thrombosis), hypoglycemia, hereditary metabolic diseases, disorders of calcium-phosphorus metabolism, diagnosis, treatment and management of osteopenia of prematurity | X | ||||
| 6. Gaining up-to-date knowledge and experience regarding fluid, electrolyte, acid-base balance disorders in newborns, acute kidney injury, disorders of coagulation system (bleeding and thrombosis), hypoglycemia, hereditary metabolic diseases, disorders of calcium-phosphorus metabolism, diagnosis, treatment and management of osteopenia of prematurity | X | ||||
| 7. Gaining up-to-date knowledge and experience regarding current, new and candidate treatment methods in neonatal diseases (mesenchymal stem cell, cellular-regenerative treatment methods), acute and enzyme / new drug treatments given to rare hereditary diseases (genetic, neurologic, metabolic etc) in neonatal period, renal replacement therapies, ECMO therapy, preoperative end postoperative care in newborn?s surgical diseases. Gains up-to-date knowledge and experience regarding medical and technical equipment used in the field of neonatology and uses computer and information technologies effectively. | X | ||||
| 7. Gaining up-to-date knowledge and experience regarding current, new and candidate treatment methods in neonatal diseases (mesenchymal stem cell, cellular-regenerative treatment methods), acute and enzyme / new drug treatments given to rare hereditary diseases (genetic, neurologic, metabolic etc) in neonatal period, renal replacement therapies, ECMO therapy, preoperative end postoperative care in newborn?s surgical diseases. Gains up-to-date knowledge and experience regarding medical and technical equipment used in the field of neonatology and uses computer and information technologies effectively. | X | ||||
| 7. Gaining up-to-date knowledge and experience regarding current, new and candidate treatment methods in neonatal diseases (mesenchymal stem cell, cellular-regenerative treatment methods), acute and enzyme / new drug treatments given to rare hereditary diseases (genetic, neurologic, metabolic etc) in neonatal period, renal replacement therapies, ECMO therapy, preoperative end postoperative care in newborn?s surgical diseases. Gains up-to-date knowledge and experience regarding medical and technical equipment used in the field of neonatology and uses computer and information technologies effectively. | X | ||||
| 8. Learning ethical principles and problems related to perinatal-neonatal period and clinical research, ethics of scientific publications, legislation and legal regulations related to clinical research, their importance for the individual and society and to give genetic advice, obeys ethical principles. As an individual, behaves appropriately to laws, regulations and legislation regarding duty rights and responsibilities and also to professional code of ethics. | X | ||||
| 8. Learning ethical principles and problems related to perinatal-neonatal period and clinical research, ethics of scientific publications, legislation and legal regulations related to clinical research, their importance for the individual and society and to give genetic advice, obeys ethical principles. As an individual, behaves appropriately to laws, regulations and legislation regarding duty rights and responsibilities and also to professional code of ethics. | X | ||||
| 8. Learning ethical principles and problems related to perinatal-neonatal period and clinical research, ethics of scientific publications, legislation and legal regulations related to clinical research, their importance for the individual and society and to give genetic advice, obeys ethical principles. As an individual, behaves appropriately to laws, regulations and legislation regarding duty rights and responsibilities and also to professional code of ethics. | X | ||||
| 9. Acquires theoretical and practical knowledge required by the field of neonatology, offers short- and long-term solutions to problems, obtains up-to-date and evidence-based scientific knowledge, follows current international literature, produces research hypothesis by combining it with scientific curiosity. Learns clinical and experimental scientific research planning; project writing, execution, finalization; scientific presentation methods; article writing methods; scientific article evaluation and basic concepts and skills related to research and publication statistics. Analyzes the results of the research with statistical methods, documents the evidence-based reports and presents them in national / international scientific fields. | X | ||||
| 9. Acquires theoretical and practical knowledge required by the field of neonatology, offers short- and long-term solutions to problems, obtains up-to-date and evidence-based scientific knowledge, follows current international literature, produces research hypothesis by combining it with scientific curiosity. Learns clinical and experimental scientific research planning; project writing, execution, finalization; scientific presentation methods; article writing methods; scientific article evaluation and basic concepts and skills related to research and publication statistics. Analyzes the results of the research with statistical methods, documents the evidence-based reports and presents them in national / international scientific fields. | X | ||||
| 9. Acquires theoretical and practical knowledge required by the field of neonatology, offers short- and long-term solutions to problems, obtains up-to-date and evidence-based scientific knowledge, follows current international literature, produces research hypothesis by combining it with scientific curiosity. Learns clinical and experimental scientific research planning; project writing, execution, finalization; scientific presentation methods; article writing methods; scientific article evaluation and basic concepts and skills related to research and publication statistics. Analyzes the results of the research with statistical methods, documents the evidence-based reports and presents them in national / international scientific fields. | X | ||||
| 10. Presentations, discussions and questions the themes related to neonatal diseases, and also his / her theoretical knowledge and opinions about applications independently or as a team manner in national and international scientific environments, defends the results within the framework of scientific evidence and ethical principles. Is sensitive and responsible for the problems related to health care and health policies concerning baby-child-mother-family and community health within the scope of Neonatology. Produces short- and long-term solutions to problems in individual and social context. Knows the importance of team work in the field of neonatology, works as a leader and / or team member, conducts research. | X | ||||
| 10. Presentations, discussions and questions the themes related to neonatal diseases, and also his / her theoretical knowledge and opinions about applications independently or as a team manner in national and international scientific environments, defends the results within the framework of scientific evidence and ethical principles. Is sensitive and responsible for the problems related to health care and health policies concerning baby-child-mother-family and community health within the scope of Neonatology. Produces short- and long-term solutions to problems in individual and social context. Knows the importance of team work in the field of neonatology, works as a leader and / or team member, conducts research. | X | ||||
| 10. Presentations, discussions and questions the themes related to neonatal diseases, and also his / her theoretical knowledge and opinions about applications independently or as a team manner in national and international scientific environments, defends the results within the framework of scientific evidence and ethical principles. Is sensitive and responsible for the problems related to health care and health policies concerning baby-child-mother-family and community health within the scope of Neonatology. Produces short- and long-term solutions to problems in individual and social context. Knows the importance of team work in the field of neonatology, works as a leader and / or team member, conducts research. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest