EAT734 - GENETIC TOXICOLOGY and TECHNIQUES
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| GENETIC TOXICOLOGY and TECHNIQUES | EAT734 | Any Semester/Year | 3 | 2 | 3 | 8 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Question and Answer | |||||
| Instructor (s) | Prof.Dr.Ülkü Ündeğer Bucurgat, Prof.Dr.Nurşen Başaran, Prof.Dr.Terken Baydar, Doç.Dr.Aylin Gürbay, Doç.Dr. Pınar Erkekoğlu, Doç.Dr. Gözde Girgin, Doç.Dr. Sevtap Aydın Dilsiz, Doç.Dr Suna Sabuncuoğlu | |||||
| Course objective | This course aims to evaluate the propable toxic effects of chemical substances on genetic material of cells, and to give the knowledge about the genotoxicity mechanisms, in vivo and in vitro genotoxicity tests. | |||||
| Learning outcomes |
| |||||
| Course Content | Basic concepts of genetic toxicology, the genotoxic mechanisms, in vivo and in vitro genotoxicity tests, the xenobiotics causing genotoxic effects. | |||||
| References | 1.Klaassen, C.D., Cassarett&Doull?s Toxicology, The Basic Science of Poisons, McGraw Hill, New York, 2001. 2.Ellenhorn, M.J., Medical Toxicology, Williams and Wilkins, Maryland, 1997 3.Hayes, A.W., Principles and Methods of Toxicology, Taylor and Francis, Ann Arbor, 2001 | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Introduction of genetic toxicology |
| Week 2 | The basic concepts of genetic toxicology |
| Week 3 | The types of genetic damage-Gene mutations |
| Week 4 | The types of genetic damage - Abberrations of chromosomal structure |
| Week 5 | The types of genetic damage ? Genome mutations |
| Week 6 | Xenobiotics causing genetic abberrations-1 |
| Week 7 | Xenobiotics causing genetic abberrations-2 |
| Week 8 | Carcinogenity and genotoxic carcinogens. |
| Week 9 | DNA repair Mechanisms |
| Week 10 | Epigenetics |
| Week 11 | The syndromes related to deficiency of DNA repair mechanisms |
| Week 12 | The genotoxicity tests-in vitro |
| Week 13 | The genotoxicity tests-in vivo |
| Week 14 | Genetic polymorphism and its toxic consequences |
| Week 15 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 0 | 0 |
| Final exam | 1 | 100 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 0 | 50 |
| Percentage of final exam contributing grade succes | 0 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 14 | 2 | 28 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 10 | 140 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 0 | 0 | 0 |
| Final Exam (Study duration) | 1 | 30 | 30 |
| Total Workload | 43 | 45 | 240 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. They have advanced and updated knowledge about the possible toxic effects of chemical, physical and biological agents. | X | ||||
| 2. They have strong information on different fields of toxicology and can integrate with different science disciplines with systematic approach. | X | ||||
| 3. They can conduct studies according to ethical principles, independently plan and carry out a project in the field of toxicology, perform advanced toxicological analyses with many different analytical techniques and evaluate the results with appropriate statistical analyses. | X | ||||
| 4. They can efficiently communicate with professional toxicologists; carry out teamwork and collaborate with national and international scientists. | X | ||||
| 5. They know different information technologies and can perform toxicoinformatic studies. | X | ||||
| 6. They can evaluate and interpret the information obtained from these analyses, elucidate different molecular pathways, discuss the results and present them in national and/or international meetings along with publishing their data in high impact journals. | X | ||||
| 7. They have information on the effects of toxic agents and pharmaceuticals in susceptible populations and different pathological conditions and on the diagnosis and the treatment of intoxications. | X | ||||
| 8. They are knowledgeable about evaluating the effects of environmental pollutants and toxic substances, nutritional and herbal supplements and food on public health and informing the public as well as the regulatory authorities about this issue. | X | ||||
| 9. They can contribute to the risk assessment and strategic decision-making processes and find the solutions for the toxicological problems encountered in daily life. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest