BYL653 - BIOLOGY of AGEING
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| BIOLOGY of AGEING | BYL653 | 2nd Semester | 3 | 0 | 3 | 8 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Question and Answer Demonstration | |||||
| Instructor (s) | Assoc. Dr. Banu Şebnem Önder | |||||
| Course objective | Aims a good understand of the various facets of the biology of ageing and longevity (evolutionary biology, biodemography, genetics, biochemistry, cell biology, endocrinology, etc.) and the relationship between them. These course will focus on more advanced molecular aspects of aging including age-associated diseases, identification of aging genes and epigenetics. | |||||
| Learning outcomes |
| |||||
| Course Content | Evolutionary theories on aging; Model organisms to study aging; Metabolic rate, and survival, differences among and within species; DNA and protein damage during aging; DNA repair and aging; Cellular aging; Mitochondria, oxidative damage and longevity; Age-associated diseases: p53, cancer, telomeres and telomerase in cancer; Exploring mechanisms of aging retardation by caloric restriction: studies in model organisms; Sirtuins: A universal link between NAD, metabolism, and aging; The role of TOR signaling in aging; Comparative genomics of aging; Genome-wide views of aging gene networks; Identification of ?aging genes?; Genetics of exceptional longevity: long-lived mutants; Determination of aging rate by coordinated resistance to multiple forms of stress; Calculation of life tables and analysis of life curve | |||||
| References | Medawar, Peter; "An Unsolved Problem of Biology" (1952). H. K. Lewis, London Comfort, Alex; "Ageing: The Biology of Senescence" (1964). Routledge & Kegan Paul, London. Rose, Michael; "Evolutionary Biology of Aging" (1991). Oxford University Press, New York. Hayflick, Leonard; "How and Why We Age" (1994). Ballantine Books, NY. Arking, Robert; "The Biology of Aging: Observations and Principles" (2006). Oxford University Press, Oxford. Recent publication about Biology of Ageing and Molecular Biology of Ageing. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Evolutionary theories on aging |
| Week 2 | Model organisms to study aging |
| Week 3 | Metabolic rate, and survival, differences among and within species |
| Week 4 | DNA and protein damage during aging; DNA repair and aging |
| Week 5 | Cellular aging: Mitochondria, oxidative damage and longevity |
| Week 6 | 1st Midterm exam |
| Week 7 | Age-associated diseases: p53, cancer, telomeres and telomerase in cancer |
| Week 8 | Exploring mechanisms of aging retardation by caloric restriction: studies in model organisms |
| Week 9 | Sirtuins: A universal link between NAD, metabolism, and aging |
| Week 10 | The role of TOR signaling in aging |
| Week 11 | Comparative genomics of aging: Genome-wide views of aging gene networks Identification of ?aging genes? |
| Week 12 | 2nd Midterm exam |
| Week 13 | Genetics of exceptional longevity: long-lived mutants |
| Week 14 | Determination of aging rate by coordinated resistance to multiple forms of stress |
| Week 15 | Calculation of life tables and analysis of life curve |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 1 | 20 |
| Seminar | 0 | 0 |
| Midterms | 2 | 30 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 3 | 50 |
| Percentage of final exam contributing grade succes | 1 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 12 | 10 | 120 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 1 | 30 | 30 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 2 | 15 | 30 |
| Final Exam (Study duration) | 1 | 20 | 20 |
| Total Workload | 30 | 78 | 242 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Improves knowledge in proficiency level based on the undergraduate level in biology or different disciplines by using scientific methods to analyse and interpret it. | X | ||||
| 2. Uses theoretical and practical knowledge obtained from his/her field in proficiency level | X | ||||
| 3. Interprets the knowledge obtained from his/her field with integrating the acquired knowledge from the other disciplines and synthesize new knowledge. | X | ||||
| 4. Gain ability to solve problems in his/her using research methods. | X | ||||
| 5. Gain ability to conduct study independently required in his/her field of specialization. | X | ||||
| 6. Improves new strategies to solve complex problems in the field of specialization. | X | ||||
| 7. Uses acquired proficiency level knowledge and skills in processes of learning in his/her field. | X | ||||
| 8. Uses computer software with computer technologies that is required in his/her field. | X | ||||
| 9. Has the ability of minding social, scientific, cultural and ethical values in the levels of collecting, interpreting and applying the data in his/her field. | X | ||||
| 10. Evaluates the important events and cases by minding the results which take part in the development of his/her field. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest