BÄ°K750 - OXYGEN RADICALS IN BIOCHEMISTRY
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| OXYGEN RADICALS IN BIOCHEMISTRY | BÄ°K750 | Any Semester/Year | 2 | 0 | 2 | 8 |
| Prequisites | None | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture | |||||
| Instructor (s) | Prof.Dr. Yasemin Aksoy | |||||
| Course objective | The course objectives are concept of radicals, effects of radicals on biological molecules, and relation with diseases, defense mechanisms of inside and outside of cell against radicals . | |||||
| Learning outcomes |
| |||||
| Course Content | Biological radicals; their synthesis, reactions, production mechanisms in body , lipid peroxidation, defense mechanisms against radicals, deseases related to radicals , radicals and aging, determination methods of radicals. | |||||
| References | 1. Barry Halliwell and John M.C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press, 3rd Ed. Reprinted in 2004, Thomson Press (India) Ltd.; 2. S. Singh, T.W. Evans Nitric oxide, the biological mediator of the decade:fact or fiction?, Series 'Clinical Physiology In Respiratory Intensive Care' edited by A. Rossi and C. Roussos, Number 14 in this series, Eur Respir J 1997; 10: 699, 707, DOI: 10.1183/09031936.97.10030699 Printed in UK; 3. Luminita Jerca, Oltita Jerca, Gabriela Mancaş, Irina Constantinescu, R.Lupuşoru, Mechanism of action and biochemical effects of nitric oxide (NO?), The Journal of Preventive Medicine, 2002; 10 (2): 35-45; 4. Wendy K. Alderton, Chris E. Cooper. and Richard G. Knowles, Nitric oxide synthases : structure, function and inhibition (Revıew Article), Biochem.J. (2001) 357, 593-615 (Printed in Great Britain) | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Chemistry of biological radicals and related reactive species |
| Week 2 | Production of oxygen radicals |
| Week 3 | In-vitro Reactions with oxygen radicals |
| Week 4 | Rections of oxygen radicals with biomolecules |
| Week 5 | Production of oxygen radicals in living systems (body) |
| Week 6 | Midterm exam I |
| Week 7 | Lipid peroxidation and peroxidation of other molecules |
| Week 8 | Protection mechanisms against radicals; enzymes |
| Week 9 | a.Protection mechanisms against radicals; small molecules b.Oxidative stress induced by exercise |
| Week 10 | Radicals and diseases |
| Week 11 | Radicals and aging |
| Week 12 | Nitric oxide radicals, production and NOS enzyme types |
| Week 13 | Reactions with NO radicals |
| Week 14 | Dedection methods of free radicals |
| Week 15 | Preparation for the exam |
| Week 16 | General exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 40 |
| Final exam | 1 | 60 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 1 | 40 |
| Percentage of final exam contributing grade succes | 1 | 60 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 2 | 28 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 12 | 168 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 1 | 22 | 22 |
| Final Exam (Study duration) | 1 | 22 | 22 |
| Total Workload | 30 | 58 | 240 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Students will be able to follow the conceptual and scientific developments related to basic measurement and evaluation techniques specific to the Exercise and Sports Physiology, and use the deep and systematic knowledge specific to the field of Exercise and Sports Physiology in their professional and academic studies. | X | ||||
| 2. Has advanced knowledge and skills of ethical values, laboratory safety and technics required for laboratory studies in Exercise and Sport Physiology; considers these values in the data collection process, interpretation and announcement of the data, and understands the importance of this issue for the individual and society. | X | ||||
| 3. Has the competency to analyse and integrate the information from other disciplines, synthesize new information, make decisions and solve problems by using theoretical and applied concepts and principles in Exercise and Sport Physiology with a critical approach. | X | ||||
| 4. Has the competency to conduct, manage and finalize original researche independently that brings innovation to the field and/or that can be applied to a different field with scientific respectability; chose the appropriate statistical methods, interpret the results of his/her work, write the report and present it in scientific meetings and publish. | X | ||||
| 5. Evaluates national/international strategies, politics and practices related to Exercise and Sports Physiology in line with the national values and country realities; contributes to the development of policies for the benefit of the individual and society. | X | ||||
| 6. Acts in compliance with legislation, professional values and ethical principles in the formation of knowledge related to Exercise and Sports Physiology, and transfers his/her academic and professional knowledge, skills and responsibilities to team work. | X | ||||
| 7. Follows the current literature on Exercise and Sport Physiology, makes critical analysis, synthesis and evaluation of new and complex ideas, reaches original results that will bring innovation to its field. | X | ||||
| 8. Knows the importance of communication with other sciences related to Exercise and Sport Physiology, uses his/her knowledge and problem solving abilities in interdisciplinary studies; uses information and communication technologies at the level required by the field. | X | ||||
| 9. Adopts lifelong learning principles, identifies his/her learning needs and goals, and contributes to quality improvement, vocational training and promotion programs in Exercise and Sports Physiology. | X | ||||
| 10. Communicates with national and international individuals and institutions, shares the knowledge, defends his/her arguments and presents his/her suggestions on the issues in Exercise and Sports Physiology. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest