BÄ°K609 - INTERCELLULAR INTERACTIONS

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
INTERCELLULAR INTERACTIONS BÄ°K609 Any Semester/Year 3 0 3 7
PrequisitesNone
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesOther: Lectures with student participation  
Instructor (s)Prof.Dr.A. Kevser Özden, Prof. Dr. Gülberk Uçar 
Course objectiveTo understand the extracellular matrix, cell-cell interactions and their interactions, their roles in development and pathology. To generate a global vision on these subjects. To privide a thorough understanding on these matters by reading and presenting related research articles. 
Learning outcomes
  1. 1. Explains why the cell membrane is not the boundary
  2. 2. Explains how the cells communicate with examples
  3. 3. Gives the names of extracellular matrix components explaining their structure and function
  4. 4. Relates cell adhesion molecules with cellular functions
  5. 5. Gives examples to extracellular matrix and cell adhesion molecule related diseases
  6. 6. Reads and avaluates research articles on these topics
Course ContentExtracellular matrix components, molecules and their signalling pathways which mediate cell-cell interactions, roles of cell-cell interaction in development and clinic. 
References1. The Cell, A Molecular Approach (2009), G. Cooper. R.E. Housman, 5th edition, ASM Press, Washington DC,
2. Molecular Biology of the Cell, B. Alberts, A. Johnson, et.al., 5th edition, Garlang Publ. Inc., New York
3. Relevant research articles in current journals 

Course outline weekly

WeeksTopics
Week 1INTRODUCTION: Multicellularity and cell environment
Week 2Extracellular matrix
Week 3Fibroblasts and collagen
Week 4Proteoglycans and glycosaminoglycans
Week 5Fibronectin and laminin
Week 6PAPER PRESENTATION
Week 7Extracellular matrix and metalloproteases
Week 8Cell-cell interactions ( selectins and Ig superfamily)
Week 9Integrins
Week 10Tight and gap junctions
Week 11PAPER PRESENTATION
Week 12Synapses
Week 13The role of intercellular interactions in signal trunsduction, differentiation and development
Week 14Clinical importance of intercellular interactions
Week 15Preparation fort he exam
Week 16FINAL EXAMINATION

Assesment methods

Course activitiesNumberPercentage
Attendance1410
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation00
Project00
Seminar240
Midterms00
Final exam150
Total100
Percentage of semester activities contributing grade succes1650
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)10220
Presentation / Seminar Preparation22448
Project000
Homework assignment8972
Midterms (Study duration)000
Final Exam (Study duration) 12828
Total Workload3566210

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. The student has detailed knowledge on biomolecules and metabolism; and applies and enhances this knowledge.    X
2. The student knows and uses the equipment and instruments specific to the field of biochemistry.     
3. The student has fundamental laboratory knowledge such as laboratory safety and basic biochemical methods, and uses this information.     
4. Knows basic statistical methods, applies this knowledge to study and interprets the results.     
5. Knows professional ethics (intellectual property, academic integrity, ethics in human relations: avoids discrimination, values merit, respects privacy etc), research and publication ethics and applies this information.     
6. Can access printed and electronic databases in the field and has the capacity to follow up recent advances in biochemistry and related fields.     
7. Comprehends the interaction of biochemistry with other disciplines and makes use of them.      
8. By means of theoretical knowledge and critical reasoning, plans the related experiments and puts into practice the relevant experimental approaches to his/her special field of study.     
9. Evaluates the results of the study, interprets the data and writes its report.      
10. Independently or with the help of an advisor can define a scientific or technical problem, propose a solution and if needed solves the problem.     
11. Takes responsibility in collaborative studies, contributes to the studies and works in harmony.     
12. Makes a presentation on a recent topic in the field of biochemistry.     
13. Presents or publishes his/her studies in a scientific meeting or a journal.     
14. Reads, comprehends, interprets and criticizes an article in the field of biochemistry.     
15. Has proficiency in English required to follow the advances in biochemistry.     

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest