EFT614 - BIODEGRADABLE POLYMERS IN DRUG DELIVERY SYSTEMS

Course Name Code Semester Theory
(hours/week)
Application
(hours/week)
Credit ECTS
BIODEGRADABLE POLYMERS IN DRUG DELIVERY SYSTEMS EFT614 Any Semester/Year 3 0 3 7
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Preparing and/or Presenting Reports
 
Instructor (s)Prof. Sema Çalış 
Course objectiveThe aim can be stated as to teach the general properties of biopolymers and rationale for designing and preparing dosage forms for drug delivery using these polymers. 
Learning outcomes
  1. On successful completion of this course, students will learn the properties of the polymers used for formulation design and as drug delivery systems, will decide the right polymer for the right formulations, discuss the current articles and book chapters on this issue.
Course ContentIn the cover of this course, the importance of biodegradable polymers from formulation aspect of pharmaceutical technology is emphasized, related terminology is defined and after a classification of biopolymers, basic knowledge concerning natural and synthetic properties of biopolymers are presented. Properties of Poly(lactide-co-glycolide) (PLGA) polymers, design and development of drug delivery system using this FDA approved biodegradable, biocompatible and synthetic polymer is also discussed in detail using update literature. 
References1. Peptide and Protein Drug Delivery, Ed. Vincent H. L. Lee, 1991, Marcel Dekker, Inc., New York-USA.
2. Formulation, Characterisation and Stability of Protein Drugs, Eds. Rodney Pearlman, Y. John Wang, 1996, Plenum Press, New York-USA.
3. Physical Methods to Characterize Pharmaceutical Proteins, Eds. James N. Herran, Wim Jiskot, Daan J. A. Crommelin, 1995, Plenum Press, New York-USA.
 

Course outline weekly

WeeksTopics
Week 1Introduction to polymers, definitions of homopolymers, copolymers and graft polymers
Week 2Classification of polymers and examples of polymer types
Week 3Introduction to biodegradable polymers
Week 4Explanations on related terminology of biodegradable polymers; biodegradation, bioresorption, bioabsorption, bioerosion and biodeteroriation
Week 5Introduction to general properties of poly (lactide-co-glycolide)(PLGA)
Week 6Synthesis of PLGA polymers, biodegradation, polymer characteristics
Week 7Polymer degradation and erosion mechanism
Week 8Discussion on current literature
Week 9Sterilization approaches for PLGA including formulations
Week 10Design of microparticulate systems prepared by PLGA polymers
Week 11Introduction to natural biodegradable polymers and general properties
Week 12Design of drug delivery systems using natural biodegradable polymers
Week 13Biomedical applications of polymeric materials
Week 14Current status of biodegradable polymers, evaluation of technological significance and future expectations
Week 15Preparation for the Final Exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation125
Project00
Seminar00
Midterms125
Final exam150
Total100
Percentage of semester activities contributing grade succes250
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14456
Presentation / Seminar Preparation11616
Project000
Homework assignment000
Midterms (Study duration)13636
Final Exam (Study duration) 16060
Total Workload31119210

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest