MEB725 - BIOLOGY of ORGANELLE DISEASES
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| BIOLOGY of ORGANELLE DISEASES | MEB725 | 3rd Semester | 3 | 0 | 3 | 7 |
| Prequisites | Limited to a quota of 10 students | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Other: Presentation, Article discussion | |||||
| Instructor (s) | Prof. Pervin Dinçer | |||||
| Course objective | After completing this course, students will learn structure and function of organelles, gain knowledge about organelle diseases, and learn cellular pathways in mechanisms of disease. | |||||
| Learning outcomes |
| |||||
| Course Content | In this course, structure and function of lysosomes, mitochondria, endoplasmic reticulum, Golgi apparatus, peroxisomes, nucleus, cell membrane, extracellular matrix and cytoskeleton, pathophsiology of the diseases related to these organelles will be discuseed. Reviews and research papers related to these issues will be read. In order to better understand the pathophysiology of the above-mentioned diseases, the students will prepare a presentation in this topic. | |||||
| References | 1. Lewis R, Human Genetics, Concepts and Applications, Mc Graw Hill, 2001. 2. Gelehrter TD, Collins FS, Ginsburg D, Principles of Medical Genetics, Williams and Wilkins, 1998. 3. Nussbaum RL, McInnes R, Willard H, Genetics in Medicine, Thompson and Thompson, 2007. 4. Alberts B, Molecular Biology of the Cell, 2007. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Structure and function of the lysosome, lysosomal storage diseases |
| Week 2 | Article discussion (Presentation) |
| Week 3 | Structure and function of the mitochondria, mitochondrial diseases |
| Week 4 | Article discussion (Presentation) |
| Week 5 | Structure and function of the endoplasmic reticulum, endoplasmic reticulum stress and related diseases |
| Week 6 | Article discussion (Presentation) |
| Week 7 | Peroxisome biogenesis and peroxisome diseases |
| Week 8 | Article discussion (Presentation) |
| Week 9 | Structure and function of the nucleus, Laminopathies |
| Week 10 | Article discussion (Presentation) |
| Week 11 | Structure and function of the golgi apparatus, protein glycosylation defects |
| Week 12 | Article discussion (Presentation) |
| Week 13 | Protein glycosylation defects (continued) |
| Week 14 | Homework assignment |
| Week 15 | Preparation for the final exam |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 1 | 25 |
| Presentation | 6 | 25 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 0 | 0 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 7 | 50 |
| Percentage of final exam contributing grade succes | 1 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 9 | 126 |
| Presentation / Seminar Preparation | 6 | 4 | 24 |
| Project | 0 | 0 | 0 |
| Homework assignment | 1 | 4 | 4 |
| Midterms (Study duration) | 0 | 0 | 0 |
| Final Exam (Study duration) | 1 | 10 | 10 |
| Total Workload | 36 | 30 | 206 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Learn and process the information in the field of cell biology at an academic level (KNOWLEDGE). | |||||
| 2. Learn and process the information in the field of molecular biology and genetics at an academic level (KNOWLEDGE). | X | ||||
| 3. Learn and process the information in the field of inheritance at an academic level (KNOWLEDGE). | X | ||||
| 4. Learn and process the information in the field of genomics and functional genomics at an academic level (KNOWLEDGE). | |||||
| 5. Have theoretical/ practical skills for preparing and carrying out an independent research project (SKILLS). | |||||
| 6. Follow and discuss national/international publications (SKILLS). | |||||
| 7. Apply ethical and legal rules at the institutional, national and international level (SKILLS). | |||||
| 8. Design and implement studies efficiently related to genomics technologies (SKILLS). | |||||
| 9. Use information technologies and bioinformatics tools effectively (SKILLS). | |||||
| 10. Take responsibility in a team and/or carry out independent research (QUALIFICATION). | |||||
| 11. Gain critical thinking and solve scientific problems in accordance with ethical reflection (QUALIFICATION). | X | ||||
| 12. Prepare scientific publications for national/international-refereed journals (QUALIFICATION). | |||||
| 13. Apply biosafety rules and follow good laboratory practices (QUALIFICATION). | |||||
| 14. Have competence in setting up a new laboratory infrastructure in the field of genomics and manage a working team (QUALIFICATION). | |||||
| 15. Make scientific presentations at the national/international meetings (QUALIFICATION). | |||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest