MEB714 - MOLECULAR BIOLOGY of CANCER
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| MOLECULAR BIOLOGY of CANCER | MEB714 | 3rd Semester | 3 | 0 | 3 | 7 |
| Prequisites | Students should be completed a course related molecular biology/genetics. Limited to a quota of 10 students. | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Other: Presentation | |||||
| Instructor (s) | Prof. Serap Dökmeci | |||||
| Course objective | The aim of this course is to teach molecular biology and genetics of cancer and discuss mechanisms in oncogenesis. | |||||
| Learning outcomes |
| |||||
| Course Content | In this course , molecular biology and genetics of cancer will be studied in detail. | |||||
| References | 1. Weinberg R A. 2007. The Biology of Cancer. The Garland Science, Taylar & Francis Group, LLC. 2. Current articles related to subject. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Properties of transformed cancer cells and the model systems used in cancer studies |
| Week 2 | Mechanisms of signal transduction, cell cycle regulation |
| Week 3 | Article discussion (Presentation) |
| Week 4 | Important genes in tumor development and metastasis, concept of oncogen, protooncogene and tumor suppressor genes |
| Week 5 | Gene product of oncogenes and mechanisms of oncogene activation |
| Week 6 | Article discussions (Presentation) |
| Week 7 | Genome variations in cancer and chemical carcinogenesis |
| Week 8 | Chromosomal rearrangements and cancer |
| Week 9 | Article discussion (Presentation) |
| Week 10 | Copy number variations and gene amplifications in oncogene activation |
| Week 11 | Tumor suppressor genes (structure and function), transforming viruses, RNA and DNA viruses in carcinogenesis |
| Week 12 | Apoptosis and cancer, multistep carcinogenesis and importance of microenviroment in tumor development |
| Week 13 | Molecular biomarkers in diagnosis and targeted therapy of cancer |
| Week 14 | Homework assignment |
| Week 15 | Preparation for the final exam |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 1 | 20 |
| Presentation | 3 | 20 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 0 | 0 |
| Final exam | 1 | 60 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 4 | 40 |
| Percentage of final exam contributing grade succes | 1 | 60 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 9 | 126 |
| Presentation / Seminar Preparation | 3 | 5 | 15 |
| Project | 0 | 0 | 0 |
| Homework assignment | 1 | 7 | 7 |
| Midterms (Study duration) | 0 | 0 | 0 |
| Final Exam (Study duration) | 1 | 15 | 15 |
| Total Workload | 33 | 39 | 205 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Learn and process the information in the field of cell biology at an academic level (KNOWLEDGE). | X | ||||
| 2. Learn and process the information in the field of molecular biology and genetics at an academic level (KNOWLEDGE). | |||||
| 3. Learn and process the information in the field of inheritance at an academic level (KNOWLEDGE). | |||||
| 4. Learn and process the information in the field of genomics and functional genomics at an academic level (KNOWLEDGE). | |||||
| 5. Have theoretical/ practical skills for preparing and carrying out an independent research project (SKILLS). | |||||
| 6. Follow and discuss national/international publications (SKILLS). | X | ||||
| 7. Apply ethical and legal rules at the institutional, national and international level (SKILLS). | |||||
| 8. Design and implement studies efficiently related to genomics technologies (SKILLS). | |||||
| 9. Use information technologies and bioinformatics tools effectively (SKILLS). | |||||
| 10. Take responsibility in a team and/or carry out independent research (QUALIFICATION). | |||||
| 11. Gain critical thinking and solve scientific problems in accordance with ethical reflection (QUALIFICATION). | |||||
| 12. Prepare scientific publications for national/international-refereed journals (QUALIFICATION). | |||||
| 13. Apply biosafety rules and follow good laboratory practices (QUALIFICATION). | |||||
| 14. Have competence in setting up a new laboratory infrastructure in the field of genomics and manage a working team (QUALIFICATION). | |||||
| 15. Make scientific presentations at the national/international meetings (QUALIFICATION). | |||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest