EAT712 - TOXIC RESPONSES of TARGET ORGANS I

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
TOXIC RESPONSES of TARGET ORGANS I EAT712 Any Semester/Year 3 0 3 8
PrequisitesNo
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
 
Instructor (s)Prof.Dr.Ãœlkü ÃœndeÄŸer Bucurgat, Prof.Dr.NurÅŸen BaÅŸaran, Prof.Dr.Terken Baydar, Doç.Dr.Aylin Gürbay, Doç.Dr. Pınar ErkekoÄŸlu, Doç.Dr. Gözde Girgin, Doç.Dr. Sevtap Aydın Dilsiz, Doç.Dr Suna SabuncuoÄŸlu 
Course objectiveDefinition of adverse effects of xenobiotics on important target organs, and giving general information about the mechanism of these effects  
Learning outcomes
  1. 1. This course will provide students with general knowledge on important target organs of organism.
  2. 2. Students have knowledge on the causes being targets of these organs in the xenobiotic toxicity, their interaction mechanisms with xenobiotics, and observed adverse effect mechanisms and outcomes.
  3. 3. Students are well informed on hepatotoxicity, and nephrotoxicity.
  4. 4. Students are well informed on immune system toxicity and cardiovascular system toxicity.
Course ContentDefinitions and basic conceps of xenobiotics, their adverse effect on important target organs such as immune, cardiovascular and renal systems and liver; mechanisms of these effects.  
References1. Winchester, JF, Haddad, LM, ?Clinical Management of poisoning and drug Overdose, Philadelphia 1983.
2. Hodgson E, Levi, PE, ?Ä°ntroduction to Biochemical Toxicology?, London 1994.
3. Klaassen, C.D., Watkins J.W., "Casarett & Doull?s Essential of Toxicology, The McGraw Hill Companies, 2010.
 

Course outline weekly

WeeksTopics
Week 1Liver Toxicity
Week 2Liver Toxicity
Week 3Liver Toxicity
Week 4Immune system components
Week 5Immune system components
Week 6Immune system components
Week 7Immune system components
Week 8Immune system components
Week 9Cardiovascular system toxicity
Week 10Cardiovascular system toxicity
Week 11Renal System
Week 12Renal System
Week 13Nefrotoxicity
Week 14Nefrotoxicity
Week 15Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation00
Project230
Seminar00
Midterms00
Final exam170
Total100
Percentage of semester activities contributing grade succes030
Percentage of final exam contributing grade succes070
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)14228
Presentation / Seminar Preparation000
Project000
Homework assignment260120
Midterms (Study duration)000
Final Exam (Study duration) 15050
Total Workload31115240

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
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1. They have advanced and updated knowledge about the possible toxic effects of chemical, physical and biological agents.    X
2. They have strong information on different fields of toxicology and can integrate with different science disciplines with systematic approach.    X
3. They can conduct studies according to ethical principles, independently plan and carry out a project in the field of toxicology, perform advanced toxicological analyses with many different analytical techniques and evaluate the results with appropriate statistical analyses.    X
4. They can efficiently communicate with professional toxicologists; carry out teamwork and collaborate with national and international scientists.    X
5. They know different information technologies and can perform toxicoinformatic studies.    X
6. They can evaluate and interpret the information obtained from these analyses, elucidate different molecular pathways, discuss the results and present them in national and/or international meetings along with publishing their data in high impact journals.  X  
7. They have information on the effects of toxic agents and pharmaceuticals in susceptible populations and different pathological conditions and on the diagnosis and the treatment of intoxications.    X
8. They are knowledgeable about evaluating the effects of environmental pollutants and toxic substances, nutritional and herbal supplements and food on public health and informing the public as well as the regulatory authorities about this issue.  X  
9. They can contribute to the risk assessment and strategic decision-making processes and find the solutions for the toxicological problems encountered in daily life.X    

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest