ERF682 - APPLIED LIPOSOME TECHNOLOGY
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| APPLIED LIPOSOME TECHNOLOGY | ERF682 | Any Semester/Year | 3 | 0 | 3 | 8 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion Drill and Practice | |||||
| Instructor (s) | Prof. Dr. A. Yekta Özer | |||||
| Course objective | The course aim is to give the students basic knowledge about preparation methods, in vitro characterization studies, in vitro and in vivo application of liposomes and other lipid based drug delivery systems. | |||||
| Learning outcomes |
| |||||
| Course Content | - Preparation of liposomes and other lipid based drug delivery systems - Properties of these drug delivery systems - Characterization studies - In vitro and in vivo studies on liposomes and other lipid based drug delivery systems | |||||
| References | 1- RRC New, Liposomes: A Practical Approach, Oxford, Oxford University Press, 1990. 2- DD Lasic, Liposomes: From Physics to Applications, Elsevier, 1993. 3- F Puisieux, P Couvreur, J Delatre, JP Devissaguet, Liposomes, New Systems and New Trends in Their Applications, Paris, Editions de Sante, 1995. 4- IF Uchegbu, Synthetic Surfactant Vesicles-Niosomes, Australia, Harwood Academic Publishers, 2000. 5- O Braun-Flaco, HC Korting, HI Maibach, Liposome Dermatics, Berlin, New York, Springer-Verlag, 1992 1992. 6- A. Gürsoy (ed). Kontrollü Salım Sistemleri, Elma Bilgisayar Basım ve Ambalaj San. Tic. Ltd. Şti., İstanbul 2002. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Introduction and definitions |
| Week 2 | Materials used in liposome preparation |
| Week 3 | Lipid selection, bilayer theory |
| Week 4 | Properties of liposomes |
| Week 5 | Encapsulation volume, encapsulation efficiency, number of bilayer, particle size and distribution measuring methods |
| Week 6 | Encapsulation volume, encapsulation efficiency, number of bilayer, particle size and distribution measuring methods (cont) |
| Week 7 | Midterm exam |
| Week 8 | Phase behavior of liposomes |
| Week 9 | Preparation methods |
| Week 10 | Stability and stability tests, lyophilization |
| Week 11 | Other vesicular drug delivery systems (sphingosomes, transferosomes, pH and temperature sensitive liposomes) |
| Week 12 | Other vesicular drug delivery systems (niosomes, lipogelosomes, niogelosomes, virosomes, ufasomes) |
| Week 13 | Other vesicular drug delivery systems (niosomes, lipogelosomes, niogelosomes, virosomes, ufasomes) |
| Week 14 | Recent studies (in-vitro, in-vivo) on other vesicular drug delivery systems (niosomes, lipogelosomes, niogelosomes, virosomes, ufasomes) |
| Week 15 | Arrangements for final exam |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 50 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 1 | 50 |
| Percentage of final exam contributing grade succes | 1 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 3 | 42 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 1 | 66 | 66 |
| Final Exam (Study duration) | 1 | 70 | 70 |
| Total Workload | 30 | 142 | 220 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Searches current information in his field. Knows how to conduct scientific research and access information sources, and evaluates and uses this information. | |||||
| 2. Designs, carries out and evaluates scientific studies using theoretical and practical knowledge at the level of expertise acquired in that field. | X | ||||
| 3. Performs statistical analysis and interpretation of data obtained from studies. | |||||
| 4. Presents the results obtained from scientific studies in scientific meetings, prepare the reports of results and publishes the results of studies in national and/or international journal. | |||||
| 5. Has the theoretical knowledge and appropriate skills on formulation, manufacturing, stability, quality assurance, regulatory affairs, and other regulations and distributions of radiopharmaceuticals. | X | ||||
| 6. Has the knowledge on effect of radiation on pharmaceutics, cosmetics and their raw materilas, drug delivery systems and medical devices and know how to control and/or prevent the possible changes occured by gamma irradiation. | |||||
| 7. Knows the biological effect of ionized radiation. Follow the rules required for radiation protection to protect the radiation worker, public and environment. | |||||
| 8. Applies the principles of GMP and GRP in whole process of life cycle of radiopharmacuticals. | |||||
| 9. Applies principles of professional development and lifelong learning, communication and social skills on professional practices. | |||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest