KHB608 - BASIC PRINCIPLES of DEVELOPMENT
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| BASIC PRINCIPLES of DEVELOPMENT | KHB608 | 2nd Semester | 3 | 0 | 3 | 7 |
| Prequisites | None | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Other: Written, oral, project presentation | |||||
| Instructor (s) | Petek KORKUSUZ (Coordinator), Teaching Assistants: Ekim TAŞKIRAN , Ayşen GÜNEL-ÖZCAN, Türkan ELDEM, Betül ÇELEBİ-SALTIK, Dilara ZEYBEK, | |||||
| Course objective | The purpose of the course is to teach at a basic level the development of stem cells in tissues and organs, and in relationship with that, the mechanisms of their appearance, processes of differentiation and behavior in mammals. | |||||
| Learning outcomes |
| |||||
| Course Content | Basic features of stem cells Developmental organization in the cells Development of tissue and organs in mammals Development of the endoderm Development of mesoderm Development of the ectoderm Multipotent stem cells in the embryo and fetüs Development and induced pluripotent stem cells | |||||
| References | 1- Essentials of Stem Cell Biology Second Edition, Editors: Lanza R, Gearhart J, Hogan B et al, 2009 Elsevier Inc., ISBN 978-0-12-374729-7 2- Biology of Stem Cells and the Molecular Basis of Stem Cell State? Dov Zipori, Humana Press, 2009, ISBN 978-1-60761-129-5 3- Stem Cell Anthology First Edition, Editor: Carlson BM, 2010 Elsevier Inc, ISBN 978-0-12-375682-4 4- Mesenchymal Stem Cell Assays and Applications Editors: Vemuri, Chase and Rao; 1st Edition, NY 2011.Carlson BM ed: Human Embryology and Developmental Biology. 3rd Edition, Mosby, 2004. 5- The Developing Human. Clinically Oriented Embryology. Editors: Moore KL, Persaud TVN. 9 th Edition, Saunders, Philadelphia, 2013. 6- Topic-related literature provided to inform the students | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Introduction to developmental biology; development pattern of cells and stem cells (Petek KORKUSUZ) |
| Week 2 | Mammalian tissue and organ development 1 (Petek KORKUSUZ) |
| Week 3 | Mammalian tissue and organ development 2 (Petek KORKUSUZ) |
| Week 4 | Mammalian tissue and organ development 3 (Ekim TAÅžKIRAN) |
| Week 5 | Molecular Mechanisms in Early Development (Ayşen GÜNEL-ÖZCAN) |
| Week 6 | Advanced Development of endoderm (N. Dilara ZEYBEK) |
| Week 7 | Midterm Exam |
| Week 8 | Advanced development of mesoderm (Betül ÇELEBİ-SALTIK) |
| Week 9 | Advanced development of ectoderm (N. Dilara ZEYBEK) |
| Week 10 | Basic Principles of Development Journal-I (AYŞEN GÜNEL-ÖZCAN) |
| Week 11 | Embryo and fetus derived multipotent stem cells I (Betül ÇELEBİ-SALTIK) |
| Week 12 | Basic Principles of Development Journal-II (Ayşen GÜNEL-ÖZCAN) |
| Week 13 | Principles of general development Journal-III (N. Dilara ZEYBEK) |
| Week 14 | Discussion |
| Week 15 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 14 | 10 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 2 | 30 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 20 |
| Final exam | 1 | 40 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 17 | 40 |
| Percentage of final exam contributing grade succes | 1 | 60 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 5 | 70 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 2 | 19 | 38 |
| Midterms (Study duration) | 1 | 20 | 20 |
| Final Exam (Study duration) | 1 | 40 | 40 |
| Total Workload | 32 | 87 | 210 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. To gain state-of-the art information on molecular structure, development and biochemical metabolism of stem cells | |||||
| 2. To understand and critically assess stem cells and interactions with their environment | |||||
| 3. To assess the roles of stem cells in tissue-organ development and function | X | ||||
| 4. To understand the role of stem cells in regenerative medicine/tissue engineering, to comprehend interactions between disciplines at an (inter)national level | |||||
| 5. To obtain knowledge and comply with legal and ethical principles for clinical use, to be aware of their importance individually and for society | |||||
| 6. To follow new developments and technologies in the field of stem cells, to be able to use equipment and materials used in basic stem cell sciences | X | ||||
| 7. To be able to use information technology professionally | X | ||||
| 8. To discuss at a (inter)national level topics related to stem cells, to possess knowledge and the long-term capability to solve problems | X | ||||
| 9. To present scientific opinions on theoretical and practical topics, to discuss these with specialists, to defend and question norms, to assess the quality-based results | X | ||||
| 10. To analyse research data obtained using statistical methods, and to report evidence based research at an (inter)national scientific level | X | ||||
| 11. To know the working standards of a stem cell laboratory, to implement the rules of data acquisition and scientific reporting, ethics and biosafety | |||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest