BÄ°K750 - OXYGEN RADICALS IN BIOCHEMISTRY

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
OXYGEN RADICALS IN BIOCHEMISTRY BÄ°K750 Any Semester/Year 2 0 2 8
PrequisitesNone
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
 
Instructor (s)Prof.Dr. Yasemin Aksoy 
Course objectiveThe course objectives are concept of radicals, effects of radicals on biological molecules, and relation with diseases, defense mechanisms of inside and outside of cell against radicals . 
Learning outcomes
  1. 1. Learns the concept of radicals
  2. 2. Understands the formation of oxygen radicals and their reactions
  3. 3. Knows the defense mechanisms of body.
  4. 4. Learns the relations of diseases with radicals
  5. 5. Learns the nitric oxide radicals and thier effects
  6. 6. Learns the determination methods of radicals.
Course ContentBiological radicals; their synthesis, reactions, production mechanisms in body , lipid peroxidation, defense mechanisms against radicals, deseases related to radicals , radicals and aging, determination methods of radicals.  
References1. Barry Halliwell and John M.C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press, 3rd Ed. Reprinted in 2004, Thomson Press (India) Ltd.;
2. S. Singh, T.W. Evans Nitric oxide, the biological mediator of the decade:fact or fiction?, Series 'Clinical Physiology In Respiratory Intensive Care' edited by A. Rossi and C. Roussos, Number 14 in this series, Eur Respir J 1997; 10: 699, 707, DOI: 10.1183/09031936.97.10030699 Printed in UK;
3. Luminita Jerca, Oltita Jerca, Gabriela MancaÅŸ, Irina Constantinescu, R.LupuÅŸoru, Mechanism of action and biochemical effects of nitric oxide (NO?), The Journal of Preventive Medicine, 2002; 10 (2): 35-45;
4. Wendy K. Alderton, Chris E. Cooper. and Richard G. Knowles, Nitric oxide synthases : structure, function and inhibition (Revıew Article), Biochem.J. (2001) 357, 593-615 (Printed in Great Britain) 

Course outline weekly

WeeksTopics
Week 1Chemistry of biological radicals and related reactive species
Week 2Production of oxygen radicals
Week 3In-vitro Reactions with oxygen radicals
Week 4Rections of oxygen radicals with biomolecules
Week 5Production of oxygen radicals in living systems (body)
Week 6Midterm exam I
Week 7Lipid peroxidation and peroxidation of other molecules
Week 8Protection mechanisms against radicals; enzymes
Week 9a.Protection mechanisms against radicals; small molecules b.Oxidative stress induced by exercise
Week 10Radicals and diseases
Week 11Radicals and aging
Week 12Nitric oxide radicals, production and NOS enzyme types
Week 13Reactions with NO radicals
Week 14Dedection methods of free radicals
Week 15Preparation for the exam
Week 16General exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments00
Presentation00
Project00
Seminar00
Midterms140
Final exam160
Total100
Percentage of semester activities contributing grade succes140
Percentage of final exam contributing grade succes160
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 2 28
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)1412168
Presentation / Seminar Preparation000
Project000
Homework assignment000
Midterms (Study duration)12222
Final Exam (Study duration) 12222
Total Workload3058240

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345
1. The student has advanced theoretical and practical knowledge on biochemistry and enhances this knowledge.    X
2. Knows professional ethics (intellectual property, academic integrity, ethics in human relations: avoids discrimination, values merit, respects privacy etc), research and publication ethics and applies this information.     
3. Reviews and analyzes the recent literature on a specific subject, formulates a unique hypothesis from this analysis and writes a project on this subject.      
4. Has advanced knowledge on the uses of instruments and methods specific to the field of biochemistry as well as other technological equipment including computers and uses them in the course of projects.      
5. Independently can head a project-based scientific work from start to finish, finalize the work, analyze the data through relevant statistical methods and contributes to progress in the field.      
6. Follows evidence based applications, does research and contributes to produce knowledge which can be put to good use in society.     
7. Writes the report of the research participated in or made by self and contributes to universal knowledge by publishing it in a peer-reviewed journal and presenting it at scientific meetings.      
8. Can formulate alternative solutions to scientific problems in the field and critically analyze and evaluate new information.      
9. Takes part in national and international multi-disciplinary studies both as leader or participant and through effective communication can relay distinctive ideas in scientific discussions and provides feed-back.      
10. Can independently manage a research laboratory and has managing and teaching skills for making strategic decisions.      
11. Is open to renovation and in continuous self development.      
12. Even without any previous experience, can structure and apply a method on if needed.     
13. Is in command of native language, can communicate at an advanced level using written, oral and visual techniques and debates.      
14. Has proficiency in English both to follow the advances in the field and to contribute to it using written, oral and visual techniques.      

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest