PBT619 - BIODEGRADABLE POLYMERS

Course Name Code Semester Theory
(hours/week)		 Application
(hours/week)		 Credit ECTS
BIODEGRADABLE POLYMERS PBT619 2nd Semester 3 0 3 10
Prequisites
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesDiscussion
Demonstration
 
Instructor (s)Prof. Dr. Kezban Ulubayram/ Doç. Dr. Eda AyÅŸe Aksoy  
Course objectiveThe main objective of this course is, teaching of students about biodegradable polymers used in biomedical and pharmaceutical fields and biodegradation mechanisms.  
Learning outcomes
  1. Student will learn the following subjects; 1. Natural and synthetic biodegradable polymers 2. Basic concepts; biostability, biodegradation, bioresorbable, bioinert, bioactive 3. Biodegradation mechanism of polymers (hydrolytic degradation, enzymatic degradation, homogeneous degradation, heterogeneous degradation, bulk degradation, surface degradation)
  2. 4. Structure?property relations of biodegradable polymers 5. Chemical and physical changes in biodegradable polymers 6. Effect of biodegradation on molecular weight change 7. Effect of biodegradation on mechanical properties
  3. 8. Biodegradation ? biocompatibility relation 9. The techniques used for examining biodegradation of polymer 10. Biodegradable polymers in hard and soft tissue regeneration, their preparation and processing techniques
  4. 11. Application areas of biodegradable polymers (Wound dressings, orthopedic products, cardiovascular materials, drug delivery systems, tissue engineering products)
  5. 12. Biodegradable polymer systems used in bioactive agent (growth factors, genetic materials, proteins, anticaogulants, drugs, etc.) carrying systems (biodegradable systems, membranes, colloids, nanosystems, thermo sensitive systems, pH sensitive systems) and their applications
Course ContentIn this course natural and synthetic biodegradable polymers, basic concepts ( biostability, biodegradation, bioresorbable, bioinert, bioactivity, biocompatibility, toxicity and biomaterial), biodegradation mechanism of polymers (hydrolytic degradation, enzymatic degradation, homogeneous degradation, heterogeneous degradation, bulk degradation, surface degradation), chemical and physical changes in biodegradable polymers, polymer structure?properties influencing biodegradation, techniques used for examining biodegradation of polymer, and medical and pharmaceutical applications of biodegradable polymers  
References? Smit Theo M, Wuisman, Paul I. J. M. Degradable Polymers for Skeletal Implants. New York : Nova Science Publishers, 2009.
? Bernhard Rieger, Andreas Konkel, Geoffrey W. Coates, Robert Reichardt, Eckhard Dinjus, Thomas A. Zevaco. Synthetic Biodegradable Polymers. Berlin, Heidelberg : Springer, 2012.
? Anthony Atala ,David J. Mooney, Joseph P. Vacanti, Robert Langer, Synthetic biodegradable polymer scaffolds, Boston Birkhauser, 1997.
 

Course outline weekly

WeeksTopics
Week 1Natural and synthetic biodegradable polymers
Week 2Basic concepts; biostability, biodegradation, bioresorbable, bioinert, bioactivite
Week 3Biodegradation mechanism of polymers (hydrolytic degradation, enzymatic degradation)
Week 4Biodegradation mechanism of polymers homogeneous degradation,
Week 5Structure?property relations of biodegradable polymers
Week 6Midterm exam
Week 7Chemical and physical changes in biodegradable polymers Effect of biodegradation on molecular weight change
Week 8Effect of biodegradation on mechanical properties
Week 9Biodegradation ? biocompatibility relation
Week 10The techniques used for examining biodegradation of polymer
Week 11Application areas of biodegradable polymers
Week 12Biodegradable polymers in hard and soft tissue regeneration, their preparation and processing techniques
Week 13Midterm exam
Week 14Biodegradable polymer systems used in bioactive agent carrying systems
Week 15Homework
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments210
Presentation00
Project00
Seminar00
Midterms240
Final exam150
Total100
Percentage of semester activities contributing grade succes050
Percentage of final exam contributing grade succes050
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)1010100
Presentation / Seminar Preparation000
Project000
Homework assignment15050
Midterms (Study duration)23570
Final Exam (Study duration) 14040
Total Workload28138302

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
12345

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest