ERF728 - EFFECTS of RADIATION ON PHARMACEUTICALS(ENG)
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| EFFECTS of RADIATION ON PHARMACEUTICALS(ENG) | ERF728 | 1st Semester | 2 | 0 | 2 | 8 |
| Prequisites | None | |||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture Discussion | |||||
| Instructor (s) | Prof. Dr. Suna Erdoğan, Assist.Prof.Dr. Mine Silindir Günay | |||||
| Course objective | The course aim is to teach the radiation effect on different pharmaceuticals, cosmetics, cosmeceutic active ingredients and their raw material and pharmaceutical dosage forms, how these effects are controlled and which measure should be taken to avoid from these effects. | |||||
| Learning outcomes |
| |||||
| Course Content | - Radiation types and applications - Radiation-material interaction - Effects of gamma radiation on different pharmaceutical active ingredients and/or excipients - Effects of gamma radiation on cosmetic and cosmeceutic active ingredient and/or excipients - Effects of gamma radiation on parenteral and ophthalmic dosage forms - Effects of gamma radiation on chemicals used in periodontology - Tests applied for observing possible effects of gamma radiation; physicochemical, chemical, spectral evaluations and biological tests etc. - Effects of gamma radiation on packaging materials | |||||
| References | 1- C Boess, C Zalewski, L Lindemann, KW Bögl. Der Einflu? der Strahlenbehandlung auf Arzneimittel und Hilfsstaffe, 1996. 2- Endüstride Radyasyonla Sterilizasyon-TAEK, 1995, 1996, 2002. | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Introduction and aim |
| Week 2 | Radiation types and applications |
| Week 3 | Radiation-material interactions |
| Week 4 | Effects of gamma radiation on different pharmaceutical active ingredients and/or excipients |
| Week 5 | Effects of gamma radiation on different pharmaceutical active ingredients and/or excipients (cont.) |
| Week 6 | Midterm exam |
| Week 7 | Effects of gamma radiation on cosmetics and cosmeceutic active ingredients and/or excipients |
| Week 8 | Effects of gamma radiation on parenteral and ophthalmic dosage forms |
| Week 9 | Effects of gamma radiation on chemicals used in periodontology |
| Week 10 | Tests applied for observing possible effect of gamma radiation; physicochemical, chemical, spectral evaluations and biological tests etc. |
| Week 11 | Tests applied for observing possible effects of gamma radiation; physicochemical, chemical, spectral evaluations and biological tests etc. (cont) |
| Week 12 | Tests applied for observing possible effects of gamma radiation; physicochemical, chemical, spectral evaluations and biological tests etc. (cont) |
| Week 13 | Effects of gamma radiation on packaging materials |
| Week 14 | Effects of gamma radiation on packaging materials |
| Week 15 | Arrangements for final exam |
| Week 16 | Final exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 1 | 50 |
| Final exam | 1 | 50 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 1 | 50 |
| Percentage of final exam contributing grade succes | 1 | 50 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 2 | 28 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 14 | 3 | 42 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 1 | 70 | 70 |
| Final Exam (Study duration) | 1 | 90 | 90 |
| Total Workload | 30 | 165 | 230 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Know the biological effects of radiation and principles of radiation protection. | X | ||||
| 2. Know radioactive substances and their properties. Uses this information in the development of new radiopharmaceuticals. | X | ||||
| 3. Know the biodistribution of radiopharmaceuticals after administration to the body, the factor that may alter the biodistribution, their localization and uptake mechanism into cells, mechanisms of action, undesirable effects, and interactions with drugs. | X | ||||
| 4. Design a new radiopharmaceutical, plans and carries out studies on its formulation, production, stability and quality assurance. Use the field-specific devices effectively during studies. | X | ||||
| 5. Know the effect of the radiation on pharmaceutics, cosmetics, active ingredients, drug delivery systems, and medical devices. Know how to control/prevent the probable variations. | X | ||||
| 6. Improve a novel idea, method, design and/or application in the field of Radiopharmacy or apply a known idea, method, design and/or application in that field or in a different field. | X | ||||
| 7. Perform a research/experimental design using current resources and perform a study, analyze the data, annotate the results. Publish the results in a national/international journal and share in scientific meetings. | X | ||||
| 8. Integrate and improve the theoretical and practical knowledge with the knowledge from different disciplines. | X | ||||
| 9. Perform the studies in the frame of ethical principles. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest