AKT703 - SURVIVAL ANALYSIS

Course Name Code Semester Theory
(hours/week)
Application
(hours/week)
Credit ECTS
SURVIVAL ANALYSIS AKT703 1st Semester 3 0 3 10
PrequisitesNone
Course languageTurkish
Course typeElective 
Mode of DeliveryFace-to-Face 
Learning and teaching strategiesLecture
Discussion
Drill and Practice
 
Instructor (s)Department Instructors 
Course objectiveThe aim of this course is to provide a statistical investigation of random lifetimes or survival models. 
Learning outcomes
  1. Define the basic concepts of survival models.
  2. Calculate the Kaplan-Meier estimate of the survivor function.
  3. Derive the partial likelihood for the Cox proportional hazards model.
  4. Identify Kolmogorov forward equations.
  5. Acquire the likelihood function for 2-state or multi-state Markov models.
  6. Acquire the asymptotic distribution of the MLE?s in multi-state Markov models.
  7. Identify the concept of exposed to risk and calculate the exposure under different assumptions.
Course ContentEstimating the lifetime distribution: cohort studies, censoring, cross-sectional studies; The Kaplan-Meier estimation of the survivor function; Cox regression model; 2-state and multi-state Markov models; binomial and Poisson models of mortality; calculation of exposure: homogeneity, the principle of correspondence, calculation of exposure from census data, adjustment of census data 
References1. Macdonald, A.S (1996), An actuarial survey of statistical models for decrement and transition data I: Multiple state models, Poisson and Binomial models, BAJ 2,I, 129-155.
2. Macdonald, A.S (1996), An actuarial survey of statistical models for decrement and transition data II: Competing risks, nonparametric and regression models, BAJ, 2,II, 429-448.
3. Macdonald, A.S (1996), An actuarial survey of statistical models for decrement and transition data III: Counting process models, nonparametric and regression models, BAJ, 2,III, 703-726.
4. Cox, D.R. (1972), Regression models and life tables, Journal of Royal Statistical Society, Series B, 34, 2, 187-220.
5. Collett, D. (2003), Modelling Survival Data in Medical Research, Chapman and Hall/CRC
6. Lecture notes
 

Course outline weekly

WeeksTopics
Week 1Introduction to survival models, notation and revision
Week 2Simple survival model, estimating the lifetime distribution: cohort studies, censoring, cross-sectional studies
Week 3The Kaplan-Meier estimation of the survivor function, standard error of Kaplan-Meier estimate; applications in R
Week 4Cox regression model, the partial likelihood function, parameter estimation, hypothesis testing and likelihood ratio test, score test and Wald test
Week 5Markov models: theory, fundamental assumptions, multi-state Markov models, Kolmogorov forward equations
Week 6Markov models: data and estimation, data and 2-state model, the MLE of the force of mortality
Week 7Midterm Exam
Week 8Markov models: estimation in the 3-state model, the likelihood in multi-state models, properties of the MLE?s
Week 9Binomial and Poisson models of mortality
Week 10Exposed to risk, homogeneity, the principle of correspondence, exact calculation of exposure
Week 11Calculation of exposure from census data, the life year rate interval, the calendar year rate interval, the policy year rate interval
Week 12Adjustment of census data, comparison of life/calendar/policy rate intervals, application in R
Week 13Presentation of posters
Week 14Presentation of posters
Week 15Preparation for Final Exam
Week 16Final exam

Assesment methods

Course activitiesNumberPercentage
Attendance00
Laboratory00
Application00
Field activities00
Specific practical training00
Assignments1010
Presentation120
Project00
Seminar00
Midterms120
Final exam150
Total100
Percentage of semester activities contributing grade succes1250
Percentage of final exam contributing grade succes150
Total100

WORKLOAD AND ECTS CALCULATION

Activities Number Duration (hour) Total Work Load
Course Duration (x14) 14 3 42
Laboratory 0 0 0
Application000
Specific practical training000
Field activities000
Study Hours Out of Class (Preliminary work, reinforcement, ect)13565
Presentation / Seminar Preparation13333
Project000
Homework assignment10990
Midterms (Study duration)13030
Final Exam (Study duration) 14040
Total Workload40120300

Matrix Of The Course Learning Outcomes Versus Program Outcomes

D.9. Key Learning OutcomesContrubition level*
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1. Develop new strategies and techniques in modelling actuarial problems and produce solutions specific to a problem.   X 
2. Conduct detailed research in a specific subject in actuarial science area.    X
3. Have the required level of competency in actuarial sciences to be able to make contribution to the actuarial literature.   X 
4. Able to use the knowledge in actuarial sciences in multidisciplinary studies.    X
5. Arrange events and projects in actuarial sciences . Able to conduct the stages of designing, executing and reporting results of a project.   X 
6. Have scientific scepticism.   X 
7. Able to produce scientific publications in the area of actuarial science.   X 
8. Able to think analytically.    X
9. Follow national and international innovations and improvements in the area.  X  
10. Follow actuarial literature  X  
11. Improve foreign language skills in order to do work and presentation in that language.     X
12. Use information technology in an advanced level.  X  
13. Able to work individually and have the ability to decide independently.    X
14. Have the qualifications necessary for a team work and able to be the team leader.  X   
15. Have the consciousness of professional and social responsibility.  X  

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest