EFK629 - THE MECHANISMS of ORGANIC REACTIONS I
| Course Name | Code | Semester | Theory (hours/week) |
Application (hours/week) |
Credit | ECTS |
|---|---|---|---|---|---|---|
| THE MECHANISMS of ORGANIC REACTIONS I | EFK629 | Any Semester/Year | 3 | 0 | 3 | 8 |
| Prequisites | ||||||
| Course language | Turkish | |||||
| Course type | Elective | |||||
| Mode of Delivery | Face-to-Face | |||||
| Learning and teaching strategies | Lecture | |||||
| Instructor (s) | Prof. Dr. Rahime Şimşek, Assoc. Prof. Keriman Özadalı Sarı | |||||
| Course objective | To give the important basic principals for organic reaction in respect to mechanistics. | |||||
| Learning outcomes |
| |||||
| Course Content | Structure of atomic orbitals, the origin of acidity in organic compounds, the forming intermediates in reactions, reaction kinetics, nucleophilic and electrophilic substitution reactions. | |||||
| References | 1. Sykes PA, ?Guidebook to Mechanism in Organic Chemistry? London 1977. 2. Solomons G, ?Organic Chemistry? New York 1978. 3. Carey FA, ?Advanced organic Chemistry? New York 1990. 4. March J, ?Advanced organic Chemistry? New York 1992. 5. Balcı M, ?Reaksiyon Mekanizmaları? TÜBA, 2009. 6. McMurry J, ?Organic Chemistry? Thomson, 2008. 7. Bruice PY, Organic Chemistry, Santa Barbara 2013 (7. Ed) 8. Klein D, Organic Chemistry, 2013 (2. Ed). | |||||
Course outline weekly
| Weeks | Topics |
|---|---|
| Week 1 | Introduction to organic chemistry and organic reaction mechanism, atomic orbitals and hybridization |
| Week 2 | Carbon-carbon single bond, carbon-carbon duble bond, carbon-carbon triple bond, structure of carbon-oksijen and carbon-nitrogen bonds |
| Week 3 | Structural formulas, calculation of formal charge, types of chemical bonds and reaction arrows, intermediate structures; electrophile and nucleophile definitions |
| Week 4 | Factors effecting the reactions; inductive and resonance effects |
| Week 5 | Acidity and factors affecting acidity |
| Week 6 | Basicity and factors affecting basicity |
| Week 7 | Conjugation and aromaticity, exercises |
| Week 8 | General concept of organic reactions and classification |
| Week 9 | Reaction kinetics |
| Week 10 | Reaction kinetics and the methods for reaction mechanism determination |
| Week 11 | Nucleophilic substution reactions (SN1) |
| Week 12 | Nucleophilic substution reactions (SN1) |
| Week 13 | Nucleophilic substution reactions (SN2) |
| Week 14 | Nucleophilic substution reactions (SN2) |
| Week 15 | Preparation to final exam |
| Week 16 | Final Exam |
Assesment methods
| Course activities | Number | Percentage |
|---|---|---|
| Attendance | 0 | 0 |
| Laboratory | 0 | 0 |
| Application | 0 | 0 |
| Field activities | 0 | 0 |
| Specific practical training | 0 | 0 |
| Assignments | 0 | 0 |
| Presentation | 0 | 0 |
| Project | 0 | 0 |
| Seminar | 0 | 0 |
| Midterms | 0 | 0 |
| Final exam | 1 | 100 |
| Total | 100 | |
| Percentage of semester activities contributing grade succes | 0 | 0 |
| Percentage of final exam contributing grade succes | 1 | 100 |
| Total | 100 | |
WORKLOAD AND ECTS CALCULATION
| Activities | Number | Duration (hour) | Total Work Load |
|---|---|---|---|
| Course Duration (x14) | 14 | 3 | 42 |
| Laboratory | 0 | 0 | 0 |
| Application | 0 | 0 | 0 |
| Specific practical training | 0 | 0 | 0 |
| Field activities | 0 | 0 | 0 |
| Study Hours Out of Class (Preliminary work, reinforcement, ect) | 13 | 12 | 156 |
| Presentation / Seminar Preparation | 0 | 0 | 0 |
| Project | 0 | 0 | 0 |
| Homework assignment | 0 | 0 | 0 |
| Midterms (Study duration) | 0 | 0 | 0 |
| Final Exam (Study duration) | 1 | 42 | 42 |
| Total Workload | 28 | 57 | 240 |
Matrix Of The Course Learning Outcomes Versus Program Outcomes
| D.9. Key Learning Outcomes | Contrubition level* | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| 1. Has the knowledge on interpretation and understanding of chemical, enstrumental and pharmacological data. | X | ||||
| 2. Knows basic concepts about medicinal chemistry such as design of new drug molecules, drug-receptor interactions. | |||||
| 3. Has the knowledge on the rules of scientific ethic which should be complied. | X | ||||
| 4. Effectively use the conventional and new sythetic methods. | X | ||||
| 5. Has the theoretical knowledge and appropriate skills on setting up laboratory installation and using laboratory equipment. | X | ||||
| 6. Has the knowledge on working safely in laboratory and guarding possible accidents in laboratory. | X | ||||
| 7. Bring solutions against unforeseen circumstances that may occur during the laboratory practices. | |||||
| 8. Use the electronic library facilities, chemical structure drawing programs and literature searching in computer as an expert. | X | ||||
| 9. Publish the results in a peer reviewed journals and present them in national/international meetings. | |||||
| 10. Have skills on studying in a research project, discussion of obtained results and prepare a report. | X | ||||
| 11. Knows a foreign language as much as he/or she can follow the scientific literature. | X | ||||
| 12. Continuously improves his/her professional knowledge and skills. | X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest